组织型纤溶酶原激活剂(TPA)是一种分泌到细胞外空间的蛋白质。它属于肽酶 S1 家族。这种蛋白质的主要功能是将纤溶酶原转化为具有生物活性的纤溶酶。作为一种蛋白酶,TPA 在调节血液纤维蛋白溶解、维持细胞外基质的平衡以及调节生长因子的翻译后活化方面发挥着至关重要的作用。
别名:Tissue-type Plasminogen Activator; t-plasminogen activator
Tissue-type plasminogen activator (TPA) is a protein that secreted into extracellular space. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin.
As a protease, TPA plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. In addition, as a cytokine, TPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.
Recombinant Human Tissue-type Plasminogen Activator (TPA) expressed the target gene encoding Ser36-Pro562 with a 6His tag at the C-terminus.
Accession: P00750
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 55-80 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Succinate, 4% Trehalose, 4% Mannitol, 0.2mM CaCl2, 0.02% Tween 80, pH 4.5.
性状 | Lyophilized powder |
溶解性(25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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