Oncostatin M又称OSM,是白细胞介素-6家族细胞因子中的一种糖蛋白,主要在细胞生长中起作用。
别名:OSM
Oncostatin M又称OSM,是白细胞介素-6家族细胞因子中的一种糖蛋白,主要在细胞生长中起作用。OSM通过含有gp130蛋白的细胞表面受体发出信号。I型受体由gp130和LIFR组成,II型受体由gp130和OSMR组成。肿瘤抑制素M (ostatin M, OSM)以前被认为具有抑制黑色素瘤和其他实体肿瘤细胞生长的能力。也有报道称OSM与LIF、IL-6、G-CSF一样具有抑制小鼠M1髓系白血病细胞增殖的能力,并能诱导其分化为巨噬细胞样细胞。
表达宿主(Expression host)
人HEK293细胞
生物活性(Biological Activity)
使用人 TF-1 细胞检测细胞增殖分析,该作用的 ED50 是 0.1-0.5ng/mL
稳定性(Stability)
冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融
溶解性(25°C) | Water Saline PBS |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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