Recombinant Human MRAP Protein (HEK293, hFc Tag) 别名：Melanocortin 2 Receptor Accessory Protein; FALP; B27; 重组人MRAP蛋白 (HEK293, hFc Tag)

目录号 M31361

MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. A DNA sequence encoding the human MRAP (Tyr59-Ser172) was expressed with the Fc region of human IgG1 at the N-terminus.

Recombinant Human MRAP Protein (HEK293, hFc Tag)结构式

规格	价格	库存状态
100ug	¥ 8800	现货

*AbMole所有产品仅供有资质的科研机构或医药企业进行科学研究或药证申报用途，不能被用于人体和任何其它用途。我们不向任何个人或非科研性质的机构提供产品和服务。

质量标准及产品资料

纯度：>90%, Endotoxin < 1 EU/µg
COA

化学性质/溶解性/储存

性状	Lyophilized powder
中文名称	重组人MRAP蛋白 (HEK293, hFc Tag)
溶解性	Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml.
储存条件	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

生物活性

MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) receptor expression and function. In adrenal cells, MRAP is essential for adrenocorticotropic hormone (ACTH)-induced activation of the cAMP/protein kinase A (PKA) pathway by melanocortin 2 receptor (MC2R), leading to glucocorticoid production and secretion.

A DNA sequence encoding the human MRAP (Tyr59-Ser172) was expressed with the Fc region of human IgG1 at the N-terminus.

The recombinant human MRAP consists 374 amino acids and predicts a molecular mass of 40.9 kDa.

Endotoxin < 1.0 EU/μg

Lyophilized from sterile PBS, pH 7.4.

实验参考

动物实验

建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。