重组人巨噬细胞迁移抑制因子(rhMIF)是大肠杆菌中产生的含有115个氨基酸的单一非糖基化多肽链。Accession # P14174。
别名：Macrophage Migration; Inhibitory Factor
种属：Human
表达系统：E. coli
纯度：> 95%经SDS-PAGE分析，> 95% HPLC分析
内毒素：凝胶凝血法测定蛋白含量< 0.2 EU/μg
表观分子量：~12.5 kDa，还原条件下SDS-PAGE
存储及稳定性：在接收后，该产品在低于-70°C的条件下保持稳定长达6个月。在重组后，产品应在4°C下稳定1周或在-20°C下稳定3个月。为了长期储存，建议添加载体蛋白(例如0.1%的牛血清白蛋白)。避免反复冻融循环。
生物活性：巨噬细胞迁移抑制因子(MIF)是一种多效细胞因子，以同型三聚体的形式存在于体内。MIF最初被认为是一种T细胞衍生因子，负责抑制巨噬细胞的迁移。近年来，由于MIF在血管生成和癌症发展中可能发挥的作用，引起了人们的广泛关注。MIF在多种癌症中都有过表达，包括胰腺癌、乳腺癌、结肠癌、脑癌、前列腺癌、皮肤癌和肺癌。MIF的瘤内表达与血管生成生长因子的表达密切相关，如白细胞介素8 (IL-8)和血管内皮生长因子(VEGF)的表达，与肿瘤切除后复发的风险密切相关。
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[3] Qingqing Xiao, et al. Acta Pharm Sin B. Biological drug and drug delivery-mediated immunotherapy
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蛋白质研究