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Recombinant Human KIAA0101 Protein (E. coli, His) 重组人KIAA0101蛋白 (E. coli, His)

目录号 M40723 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). KIAA11 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC).

Recombinant Human KIAA0101 Protein (E. coli, His)结构式

别名:p15/PAF Protein; OEATC-1

规格 价格 库存状态
50ug ¥ 8190 中国库存现货
其他规格数量报价?

质量标准及产品资料
生物活性

KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC). KIAA11 is expressed predominantly in the liver, pancreas, and placenta.

The recombinant human PAF consisting of 126 amino acids and has a calculated molecular mass of 13.8 KDa.

A DNA sequence encoding the human PAF isoform 1 (Met 1-Glu 111) was expressed, with a polyhistide tag at the N-terminus.

Lyophilized from sterile PBS, pH 7.5.

化学性质
性状 Lyophilized powder
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
储存条件 Stored at ≤ -20°C, stable for up to one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Henriett Butz et al. Clin Chem. Integrative bioinformatics analysis reveals new prognostic biomarkers of clear cell renal cell carcinoma

[2] Cai-feng Zhang et al. Zhonghua Bing Li Xue Za Zhi. [Effects of KIAA0101 expression on proliferation and invasion of gastric carcinoma MKN-45 cells]

[3] Lijuan Liu et al. Hepatology. Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibiting p53 activation

[4] Zeina Kais et al. Mol Cancer Res. KIAA0101 interacts with BRCA1 and regulates centrosome number

[5] Masayo Hosokawa et al. Cancer Res. Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer

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