ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions.
别名：IA2; R-PTP-N; Islet cell antigen 512
ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Recombinant Human ICA 512/PTPRN expressed the target gene encoding Gln607-Asn686&Trp795-Leu888 with a 6His tag at the N-terminus.
Accession: Q16849
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 26-30 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0.
This product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.
| 性状 | Solution |
| 储存条件 | Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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