重组人Galectin 9由人类细胞表达系统产生,编码Met1-Thr323的目的基因在c端用6His标记表达。蛋白编号:Q3B8N1-2。
别名:Galectin-9; Gal-9; Ecalectin; Tumor Antigen HOM-HD-21
种属:Human
表达系统:Human Cells
纯度:经还原SDS-PAGE测定,大于95%
内毒素:LAL测试测得小于0.1 ng/µg (1eu /µg)
分子量:36.7 KDa
存储及稳定性:冻干蛋白应在< -20℃下保存,但在室温下可稳定保存3周。重组蛋白溶液可在4-7℃保存2-7天。、重组样品的等分线在< -20°C下稳定3个月。
生物活性:半乳糖凝集素-9是一种含有两个半乳糖凝集素结构域的细胞质蛋白。半乳糖凝集素-9是一种s型凝集素,在何杰金氏病组织中过度表达。半乳糖凝集素-9结合半乳糖苷,对福斯曼五糖有较高的亲和力。半乳糖凝集素-9在胸腺细胞-上皮细胞的相互作用中起作用,与胸腺的生物学相关,并抑制细胞增殖。Galectin-9是HAVCR2/TIM3的配体,可诱导t辅助性1型淋巴细胞(Th1)死亡。此外,Galectin-9通过干扰CD44、VCAM-1、Integrin α4β1等因子的作用抑制肿瘤细胞转移。
溶解性(25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
[5] Valerie R Wiersma, et al. Med Res Rev. Therapeutic potential of Galectin-9 in human disease
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