重组人 CD14 由哺乳动物表达系统产生，编码 Thr20-Cys352 的靶基因在 C 末端带有 6His 标签。CD14 是一种细胞表面糖蛋白，优先在单核细胞/巨噬细胞上表达。CD14 通过与糖基磷脂酰肌醇 (GPI) 的连接固定在细胞上，并作为结合脂多糖 (LPS) 和来自不同微生物来源的各种配体的模式识别受体发挥作用。
别名：Monocyte Differentiation Antigen CD14
重组人 CD14 由哺乳动物表达系统产生，编码 Thr20-Cys352 的靶基因在 C 末端带有 6His 标签。CD14 是一种细胞表面糖蛋白，优先在单核细胞/巨噬细胞上表达。CD14 通过与糖基磷脂酰肌醇 (GPI) 的连接固定在细胞上，并作为结合脂多糖 (LPS) 和来自不同微生物来源的各种配体的模式识别受体发挥作用。CD14 与 LPS 的结合由 LPS 结合蛋白 (LBP) 催化。Toll 样受体也与 CD14-LPS 信号的转导有关。可溶性 CD14 可通过磷脂酰肌醇特异性磷脂酶 C 从细胞表面释放，并已在血清和体液中检测到。高浓度的可溶性 CD14 已显示可抑制 LPS 介导的反应。然而，可溶性 CD14 也可以增强不表达细胞表面 CD14 的细胞中的 LPS 反应。
蛋白编号： P08571
表观分子量： 54 KDa，还原条件
剂型描述： 从 20mM PB、150mM NaCl、pH 7.4 的 0.2 μm 过滤溶液中冻干。
| 溶解性（25°C） | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[2] Phuong Dao-Ung, et al. Purinergic Signal. Paroxetine suppresses recombinant human P2X7 responses
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