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Recombinant Human Carboxypeptidase CPM (Mammalian,C-6His) 重组人Carboxypeptidase CPM蛋白(Mammalian,C-6His)

目录号 M15014 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人Carboxypeptidase CPM蛋白(Mammalian,C-6His)是由哺乳动物表达系统产生的,目的基因编码Leu18-His422在c端以6His标记表达。

Recombinant Human Carboxypeptidase CPM (Mammalian,C-6His)结构式

别名:Carboxypeptidase M;CPM

规格 价格 库存状态
10ug ¥ 2400 4-6天货期
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin < 1 EU/ug
  • COA
  • MSDS
生物活性

纯度:还原SDS-PAGE测定大于95%

内毒素:经LAL测试,小于0.1 ng/ug (1 EU/ug)

存储及稳定性:存放温度≤-70℃,收货后可稳定存放6个月。开封后,在无菌条件下保存3个月,保存温度≤-70℃。请尽量减少冻融循环。


生物活性:羧肽酶M (CPM)可以特异性地从多肽和蛋白质中去除c端碱基(精氨酸或赖氨酸)。羧肽酶在凝血/纤溶、炎症、食物消化、促激素和神经肽加工等生理过程中发挥作用。CPM被认为在控制细胞表面的肽激素和生长因子活性,以及在细胞外蛋白的膜定位降解中发挥重要作用。它广泛分布于各种组织和细胞中。CPM参与细胞表面和细胞外液的肽代谢。CPM不仅是一种蛋白酶,而且是细胞表面蛋白-蛋白相互作用的结合伙伴。

化学性质
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Xianming Zhang, et al. J Biol Chem. Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor

[2] Leah Marquez-Curtis, et al. Stem Cells. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?

[3] Cora Keil, et al. J Mol Biol. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain

[4] R B Craveiro, et al. Braz J Med Biol Res. High expression of human carboxypeptidase M in Pichia pastoris: purification and partial characterization

[5] Jingqiu Li, et al. Gene. Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements

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