Recombinant Human B4GALT1 (Mammalian, C-6His) 重组人B4GALT1 蛋白(Mammalian, C-6His)

目录号 M19993 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

重组人β -1,4-半乳糖转移酶1是由哺乳动物表达系统产生的，目的基因编码Gly44-Ser398(Tyr285Leu)在c端表达6His标签。蛋白编号：P15291。

Recombinant Human B4GALT1 (Mammalian, C-6His)结构式

别名：1,4- galactosyltransferase, polypeptide 1; B4GalT1

规格	价格	库存状态
10ug	¥ 2340	1-2周货期
50ug	¥ 6480	1-2周货期

其他规格数量报价？

质量标准及产品资料

纯度： >95% , Endotoxin < 1 EU/µg
COA
MSDS

产品信息

生物活性

种属：Human

表达系统：Mammalian

表观分子量：50- 60kda，还原条件

内毒素：经LAL检验小于0.1 ng/µg (1 EU/µg)

纯度：还原SDS-PAGE测定大于95%

存储及稳定性：存放温度≤-70℃，收货后可稳定存放6个月。开封后，在无菌条件下保存3个月，保存温度≤-70℃。请尽量减少冻融循环。

生物活性：Beta1,4-半乳糖转移酶i (B4GALT1)， 7个Beta1,4-半乳糖转移酶之一，是一种常见的酶，在反式高尔基复合体中发现，将半乳糖添加到低聚糖。根据序列相似性，beta 4GalTs分为四组:beta 4GalT1和beta 4GalT2、beta 4GalT3和beta 4GalT4、beta 4GalT5和beta 4GalT6、beta 4GalT7。β 4GalT1在七种酶中是独特的，因为它既可以以膜相关形式表达，也可以以分泌形式表达。分泌型仅限于泌乳乳腺组织，该酶与-乳清蛋白形成异二聚体催化乳糖的合成。高尔基复合体在哺乳的乳腺中催化乳糖的产生，也可能负责合成许多糖蛋白中的复合型n -链接低聚糖以及糖脂的碳水化合物部分。在各种细胞与细胞和细胞与基质的相互作用中，如在发育和卵子受精过程中，细胞表面形态作为一种识别分子，通过与对立细胞或细胞外基质上的特定寡糖配体结合。β 4GalT1缺陷是先天性糖基化型2D (CDG2D)的原因。

化学性质

储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

参考文献

[1] Ngan T B Nguyen, et al. Sci Rep. Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans

[2] Daniel Taliun, et al. Nature. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

[3] Sodbo Zh Sharapov, et al. Glycobiology. Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts

[4] Joachim Steen Larsen, et al. Glycobiology. Engineering mammalian cells to produce plant-specific N-glycosylation on proteins

[5] Christoph Geisler, et al. J Biotechnol. Engineering β1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells

获取最新目录册

其他相关的Recombinant Proteins产品
Recombinant Human Serpin A12 (E.coli, N-GST) Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity.
Recombinant Human B2M Protein (Mammalian, C-6His) β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states.
Recombinant Mouse E-Selectin/CD62E Protein (HEK293) E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis.
Recombinant Human DPP4/CD26 (Mammalian, C-6His) DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
Recombinant Human USP14 (E.coli, N-6His) USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.

信号通路

产品类型

Recombinant Human B4GALT1 (Mammalian, C-6His) 重组人B4GALT1 蛋白(Mammalian, C-6His)

目录号 M19993 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

质量标准及产品资料

生物活性

化学性质

参考文献

AbMole

服务与支持

技术资源

联系我们