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Recombinant Human PDGF-BB (E. coli)

目录号 M11488 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


蛋白构造:PDGF-BB (Ser82-Thr190) Accession # P01127 生物活性:在BALB/c 3T3细胞的细胞增殖实验中,这种效应的ED50小于10 ng/ml

Recombinant Human PDGF-BB (E. coli)结构式

别名:PDGFBB; PDGF-BB

规格 价格 库存状态
10ug ¥ 2745 中国库存现货
100ug ¥ 11205 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin ≤ 0.2 EU/μg
  • COA
  • MSDS
生物活性

表达系统:E. coli

纯度:SDS-PAGE分析≥98%

内毒素:凝胶凝血法测定蛋白质≤0.2 EU/μg

表观分子量:~ 25kda,在非还原条件下SDS-PAGE

存储及稳定性:在接收后,该产品在低于-70°C的环境下保持稳定长达6个月。重组后,产品应在4°C下稳定1周或在-20°C下稳定3个月。避免反复的冻融循环。


生物活性:血小板源性生长因子(platelet derived growth factor, PDGF)是20世纪80年代末由Lynch及其同事在动物实验中首次发现的,主要存在于血清中,但不存在于血浆中。它是一个二硫键连接的二聚体,由两个肽链a和b组成。PDGF有三个亚基:PDGF- aa, PDGF- bb, PDGF- ab。它参与许多生物学过程,包括增生、胚胎神经元发育、趋化和呼吸小管上皮细胞发育。PDGF的功能是由两个受体介导的(PDGFR-α和PDGFR-β)。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Lei Chen, et al. Mol Med Rep. Inhibition of PDGF-BB reduces alkali-induced corneal neovascularization in mice

[2] Feifei Li, et al. Sci Rep. Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis

[3] Cynthia Scheines, et al. Int J Oral Maxillofac Implants. Recombinant Human Platelet-Derived Growth Factor-BB in Human Alveolar Ridge Augmentation: A Review of the Literature

[4] Feifei Li, et al. Sci Rep. Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis

[5] Christopher W DiGiovanni, et al. Expert Rev Med Devices. Recombinant human PDGF-BB in foot and ankle fusion

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