ML385 别名：ML-385

目录号 M8692

ML385是一种特异性的 NRF2 抑制剂，IC50 为1.9 μM。ML385通过结合Neh1抑制Nrf2转录因子的活性。

CAS No.：846557-71-9

规格	价格	库存状态
Free Sample (0.5-1 mg)	¥ 0	现货
10mM*1mL in DMSO	¥ 660	现货
1mg	¥ 245	现货
5mg	¥ 600	现货
10mg	¥ 1050	现货
25mg	¥ 1980	现货
50mg	¥ 2890	现货

*AbMole所有产品仅供有资质的科研机构或医药企业进行科学研究或药证申报用途，不能被用于人体和任何其它用途。我们不向任何个人或非科研性质的机构提供产品和服务。

客户使用AbMole的ML385发表的文献

J Cancer. 2025 Jan 01;16(2):417-429.

TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis

Int J Biol Sci. 2024 Aug 07.

The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage

Front. Pharmacol. 2024 Jun 28; .

Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities

Neuromolecular Med. 2024 Oct 10;26(1):40.

Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice

J Biochem Mol Toxicol. 2024 Aug 01;38(8):e23792.

Ezetimibe ketone protects against renal ischemia–reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway

Neuroscience. 2024 Aug 20;559:26-38.

The mechanism of hypoxia-inducible factor-1α enhancing the transcriptional activity of transferrin ferroportin 1 and regulating the Nrf2/HO-1 pathway in ferroptosis after cerebral ischemic injury

Nat Prod Commun. 2024 Jan.

Pachymic Acid Alleviates Oxidative Damage of Retinal Cells Induced by Sodium Iodate or Hydrogen Peroxide by Activating the Nrf2/HO-1 Signaling Pathway

Mol Cell Toxicol. 2024 May.

Liquiritin alleviates LPS-stimulated podocyte apoptosis and inflammation by activating Nrf2 signaling

Free Radic Biol Med. 2023 Mar 27;202:46-61.

Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)–NF–кB axis

Phytomedicine. 2023 Mar 28.

15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2

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Int J Pharm. 2023 Sep 13;645:123389.

Effective myocardial infarction treatment by targeted accumulation of Sulforaphane using porous magnetic silica nanoparticles

Int Immunopharmacol. 2023 May 22;120:110282.

Melatonin attenuates lipopolysaccharide-induced immune dysfunction in dendritic cells

J Cancer Res Clin Oncol. 2023 Apr 29.

Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer

PLoS One. 2023 Sep 8;18(9):e0290264.

Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression

Mol Med Rep. 2023 Nov;28(5):202.

Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death

Front Immunol. 2022 Feb 4;13:847861.

Allicin Improves Intestinal Epithelial Barrier Function and Prevents LPS-Induced Barrier Damages of Intestinal Epithelial Cell Monolayers

Free Radic Biol Med. 2022 Nov 3;193(Pt 1):459-473.

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Food Res Int. 2022 Sep 12.

N-3 Polyunsaturated Fatty Acids Protect Esophageal Epithelial Cells from Acid Exposure

Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.

Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure

Front Pharmacol. 2022 Jul 18;13:943111.

(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H 2 O 2 Through Activation of Nrf2 Pathway

Pharm Biol. 2022 Dec;60(1):638-651.

In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

Exp Ther Med. 2022 May;23(5):358.

Leonurine: A compound with the potential to prevent acute lung injury

Front Oncol. 2021 May 26;11:679816.

Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop

Biomed Res Int. 2021 Jun 10;2021:6616547.

Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway

Pharmacol Res Perspect. 2021 May;9(3):e00791.

Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway

Med J Chin PLA. 2021 Mar 28;Vol. 46, No. 3.

Anti-aging effects of Schisandrin C on H2O2-induced HaCaT

质量标准及产品资料

纯度：100.00%
COA
LC/MS

化学性质/溶解性/储存

分子量	511.59
分子式	C29H25N3O4S
CAS号	846557-71-9
溶解性	DMSO ≥ 25 mg/mL
储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

生物活性

ML385通过结合Neh1抑制Nrf2转录因子的活性。Neh1是一个nc-bzip结构域，允许Nrf2与小Maf蛋白异质二聚，阻断Nrf2的转录活性。由于Nrf2能诱导细胞保护抗氧化基因，因此对其进行了大量的活化研究。然而，一些癌细胞可能以类似的方式利用Nrf2来生存。Nrf2在某些癌症中过表达，如非小细胞肺癌(NSCLC)，通常是由于KEAP1功能突变丢失，而KEAP1是Nrf2蛋白酶体降解的靶点。ML385对KEAP1突变的NSCLC细胞具有特异性和选择性的抗肿瘤活性。

实验参考

蛋白/细胞实验

下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.9547 mL	9.7735 mL	19.5469 mL
5 mM	0.3909 mL	1.9547 mL	3.9094 mL
10 mM	0.1955 mL	0.9773 mL	1.9547 mL

*吸湿的DMSO对产品的溶解度有显著影响，请使用新开封的DMSO；
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

质量		浓度		体积		分子量*
	=		x		x

动物实验

建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。