Imidaclopride (吡虫啉)对昆虫具有选择性毒性,可以破坏代谢稳态,导致肥胖,并通过抑制细胞色素P450 (CYP)酶活性破坏类固醇生成。
别名:Imidacloprid
Imidaclopride is a systemic insecticide which acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids which act on the central nervous system of insects with much lower toxicity to mammals. The chemical works by interfering with the transmission of stimuli in the insect nervous system. Specifically, it causes a blockage in the nicotinergic neuronal pathway. This blockage leads to the accumulation of acetylcholine, an important neurotransmitter, resulting in the insect's paralysis, and eventually death. It is effective on contact and via stomach action. Imidacloprid is currently the most widely used insecticide in the world. Imidacloprid is widely used for pest control in agriculture. Other uses include application to foundations to prevent termite damage, pest control for gardens and turf, treatment of domestic pets to control fleas, and protection of trees from boring insects.
分子量 | 255.66 |
分子式 | C9H10ClN5O2 |
CAS号 | 138261-41-3 |
溶解性(25°C) | DMSO 100 mg/mL |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前,需考虑其在不同溶剂中的溶解度限制。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.9114 mL | 19.5572 mL | 39.1144 mL |
5 mM | 0.7823 mL | 3.9114 mL | 7.8229 mL |
10 mM | 0.3911 mL | 1.9557 mL | 3.9114 mL |
小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
动物 A的Km系数 |
例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。
其他相关的Cytochrome P450 (e.g. CYP17)产品 |
---|
Cytochrome P450 reductase
Cytochrome P450 reductase 是一种 NADPH-细胞色素还原酶。 |
20-SOLA
20-SOLA是一种水溶性的20-HETE拮抗剂。 |
TS-011
TS-011是一种 20-羟基二十碳四烯酸(20-HETE)合成的选择性抑制剂。 |
Dibromo-dodecenyl-methylsulfimide
Dibromo-dodecenyl-methylsulfimide是一种选择性的20-HETE合成抑制剂,并可减弱硝普钠 (SNP) 的血管舒张反应。 |
Abiraterone decanoate
Abiraterone decanoate是一种新型的,长效的Abiraterone前体化合物,同时具有高的CYP17裂解酶抑制选择性,可用于前列腺癌的相关研究。 |
产品仅供科学研究或药证申报的用途使用,不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号