生物活性：CD137(也称作 4-1BB)，CD137是一种可诱导的细胞表面受体，属于肿瘤坏死因子受体( tumornecrosis factor receptor, TNFR)超家族成员。
表达宿主：HEK-293 细胞
纯度：> 95%，采用 SDS-PAGE 凝胶和高效液相色谱分析
内毒素：＜0.01EU/μg
存储及稳定性：2~8℃保存，有效期为 24 个月。 如需分装，分装后置于-20℃保存期 6 个月，-80℃保存期 12 个月，避免反复冻融。
生物活性：CD137（也称作 4-1BB），CD137 是一种可诱导的细胞表面受体，属于肿瘤坏死因子受体( tumornecrosis factor receptor, TNFR)超家族成员，由肿瘤坏死因子受体超家族成员 9（TNFRSF9）基因编码。广泛表达于激活后的 T 细胞、NK 细胞等人体免疫细胞的表面。它的配体是 CD137L，也属于 TNFSF 成员，是在活化的 CD4+ 和 CD8+ T 细胞、NKT、NK 细胞、DC、巨噬细胞、嗜酸性粒细胞、嗜中性粒细胞和肥大细胞表达的诱导型共刺激受体，特别是在 CD8+ T 细胞上。CD137/CD137L 通过在免疫细胞间传递活化、增殖或者凋亡信号来调节 T 细胞介导的免疫反应。CD137 的活化信号转导可以刺激 NK 细胞和 T 细胞增殖并产生抗肿瘤活性，并产生持久的记忆应答。利用激活型 4-1BB 单抗激活 4-1BB，4-1BB 募集 TNFR 相关因子 TRAF1 和 TRAF2 形成异源三聚体，通过 c-Jun N 末端激酶（JNK）途径，细胞外信号调节激酶（ERK）途径等加强信号转导，并通过主转录因子 NF-κB 调节 4-1BB信号，刺激 T 细胞和抗原提呈细胞增殖并分泌细胞因子，提高机体的抗肿瘤免疫应答水平。
| 储存条件 | 2-8℃ |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
| 其他相关的Recombinant Proteins产品 |
|---|
| Recombinant Human USP14 (E.coli, N-6His)
USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
| Recombinant Human EpCAM/Trop-1 (Mammalian, C-Fc)
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein. EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli, aa 18-169, His Tag)
The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli)
The recombinant human IL1F9 consisting of 169 amino acids and has a calculated molecular mass of 18.9 kDa. A DNA sequence encoding the human IL-1F9 isoform 1 (Met 1-Asp 169) was expressed. |
| Recombinant Human APOL1 Protein (Baculovirus-Insect, C-His)
APOL1, also known as apolipoprotein L1, belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. |
产品仅供科学研究或药证申报的用途使用，不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号
蛋白质研究