找到约 8 条 “NF-κB-IN-8” 相关结果 （用时 0.118 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M42748 | NF-κB-IN-8 | NF-κB-IN-8 | NF-κB |
| NF-κB-IN-8 竞争性拮抗 LPS 与 MD-2 的结合。 | |||
M4075
|
Ginsenoside-Rd | 人参皂苷Rd | NF-κB |
| Gypenoside VIII | |||
| Ginsenoside Rd 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 12.05±0.82 μM。Ginsenoside Rd 抑制 COX-2 和 iNOS mRNA 的表达。Ginsenoside Rd 还抑制 Ca2+ 内流。Ginsenoside Rd 抑制CYP2D6，CYP1A2，CYP3A4 和 CYP2C9，IC50 分别为 58.0±4.5 μM，78.4±5.3 μM，81.7±2.6 μM 和 85.1±9.1 μM。 | |||
| M4523
|
Specnuezhenide | 特女贞苷；来源于女贞 | NF-κB |
| Specnuezhenide ((8E)-Nuezhenide) 是从女贞子的果实中分离出来的。Specnuezhenide ((8E)-Nuezhenide) 可通过抑制 NF-κB 和 wnt/β-catenin 信号传导来抑制 IL-1β 诱导的软骨细胞炎症。Specnuezhenide ((8E)-Nuezhenide) 可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。 | |||
| M4608
|
Swertiamarin | 獐牙菜苦苷 | NF-κB |
| Swertiamarin（獐牙菜苦苷）是一种发现于龙胆科植物中的裂环烯醚萜苷，可通过调节NF-κB/IκB和JAK2/STAT3信号传导抑制关节炎的发展。此外，Swertiamarin能以剂量依赖性方式抑制p38 MAPKα的水平，以及通过以时间依赖性方式，显著减弱p38 MAPKα的释放，具有抗炎和抗肿瘤活性。 | |||
| M4680
|
Mollugin | 大叶茜草素 | NF-κB |
| Rubimaillin | |||
| Mollugin 是 Rubia cordifolia L. 中主要的一种生物活性成分。Mollugin 通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。Mollugin 能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。 | |||
| M42741 | NF-κB-IN-9 | NF-κB-IN-9 | NF-κB |
| NF-κB-IN-9 是一种靶向核因子 NF-κB 的声敏剂 (λex/λem=489/628 nm)。 | |||
| M55381
|
Recombinant Human IL-25/IL-17E (HEK293, C-6His) | 重组人IL-25/IL-17E (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | |||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | |||
| M55382
|
Recombinant Human IL-25/IL-17E (E. coli, C-His) | 重组人IL-25/IL-17E (E. coli, C-His) | Cytokines and Growth Factors |
| Interleukin-25; Interleukin-17E | |||
| Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. | |||
