找到约 3 条 “L-2-Hydroxyglutaric acid disodium” 相关结果 （用时 0.107 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M20864 | L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium | Histone demethylase |
| (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG | |||
| L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively. | |||
| M30059 | α-Hydroxyglutaric acid disodium | α-Hydroxyglutaric acid disodium | Histone demethylase |
| 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium | |||
| α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid disodium 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。 | |||
M14107
|
D-α-Hydroxyglutaric acid disodium | (R)-2-羟基戊二酸二钠盐 | ROS |
| Disodium (R)-2-hydroxyglutarate | |||
| D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate，(R)-2-羟基戊二酸二钠盐) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物，也是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂，可抑制多种 α-KG 依赖性双加氧酶 (dioxygenases)，Ki 为 10.87 mM。此外，D-α-Hydroxyglutaric acid disodium也可增加活性氧 (ROS) 的产生。 | |||
