找到约 24 条 “CY3-SE” 相关结果 （用时 0.136 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M10195
|
MOG (35-55) (Mouse, rat) | 髓鞘少突胶质细胞糖蛋白 | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein (35-55) (Mouse, rat) | |||
| MOG (35-55) (Mouse, rat)（髓鞘少突胶质细胞糖蛋白）是中枢神经鞘的一个次要成分，能诱导强效的T细胞和B细胞反应。可用于构建实验性自身免疫脑脊髓炎(EAE)模型。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 有致脑炎活性，诱导 T 细胞增殖。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat 诱导 Th1 细胞因子反应以及相对高水平的 IgG 抗体出现。 | |||
| M14818
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Peptides |
| MOG (35-55) (TFA) | |||
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA)引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应，同时是高度脑源性的。 | |||
| M31321 | CY3-SE | CY3-SE | Fluorescent Dye |
| CY3 NHS ESTER | |||
| CY3-SE（CY3 NHS ESTER）是一种近红外荧光标记染料，可用于标记肽，蛋白质和寡聚体等生物分子。 | |||
| M54197 | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat | Animal Modeling |
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。 | |||
| M4009
|
Licochalcone-B | 甘草查尔酮B | Caspase |
| Licochalcone-B（LicoB，甘草查尔酮B）是一种黄酮类的天然酚，可以从甘草Glycyrrhiza glabra或Glycyrrhiza inflata的根部分离，是NLRP3炎症小体的特异性抑制剂，也可通过促进凋亡相关的Caspase-3的裂解来诱导细胞凋亡，同时抑制PI3K/AKT/mTOR途径来诱导自噬（autophagy）。*建议现配现用 | |||
| M6452
|
Apocynin | 香草乙酮；罗布麻宁 | NADPH Oxidase |
| Acetovanillone | |||
| Apocynin（香草乙酮，罗布麻宁）是一种存在于pocynum cannabinum和 Picrorhiza kurroa根部的天然产物，同时也是NADPH氧化酶(NOX)的抑制剂，可防止其p47phox亚单位向质膜转移。Apocynin（香草乙酮） 逆转间充质干细胞的衰老过程，促进成骨，增加骨量。此外，Apocynin还能抑制嗜铬细胞瘤中的P38/MAPK/Caspase3途径，胰腺癌中的AKT-GSK3β和ERK1/2途径，以及肝细胞癌中的FAK/PI3K/Akt信号，具有抗癌活性。 | |||
| M8431
|
CYM50358 | CYM50358 | S1P Receptor |
| CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). | |||
| M8767 | MIND4-17 | MIND4-17 | Others |
| MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1). | |||
| M20389 | Quisinostat (JNJ-26481585) 2HCl | Quisinostat (JNJ-26481585) 2HCl | HDAC |
| Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11 greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. | |||
| M20390 | TAK-700 (Orteronel) | TAK-700 (Orteronel) | Cytochrome P450 (e.g. CYP17) |
| TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3. | |||
| M20697 | Triglycidyl Isocyanurate (Teroxirone) | Triglycidyl Isocyanurate (Teroxirone) | p53 |
| Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC | |||
| Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. | |||
| M20706 | HQNO | HQNO | Others |
| 2-heptyl-4-hydroxyquinoline-N-oxide | |||
| HQNO is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione. | |||
| M25536
|
Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | |||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
| M27921 | BI 653048 | BI 653048 | GCR |
| BI 653048 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 也是一种 HCV NS3 protease 抑制剂，可以减少感染丙型肝炎病毒的病毒载量。 | |||
| M27922 | BI 653048 phosphate | BI 653048 phosphate | GCR |
| BI 653048 phosphate 是一种选择性且口服的非甾体类糖皮质激素 (glucocorticoid (GC)) 激动剂，其 IC50 值为 55 nM。BI 653048 phosphate 抑制 CP1A2，CYP2D6，CYP2C9，CYP2C19 和 CYP3A4 的活性并降低对 hERG 离子通道的亲和力 (IC50>30 μM)。BI 653048 phosphate 也是一种 HCV NS3 protease 抑制剂。 | |||
| M28118 | Cyclotheonamide A | Cyclotheonamide A | Serine/Threonine Protease |
| Cyclotheonamide A 是一种丝氨酸蛋白酶 (serine protease) 抑制剂 (环状多肽)，可从 Theonella 属的海洋海绵中获得。Cyclotheonamide A 对 trypsin (Ki=0.023 µM) 和 streptokinase (Ki=0.035 µM) 显示强效的抑制活性，对人 α-thrombin (Ki=0.18 µM) 显示中等抑制活性。Cyclotheonamide A 可用于抗血栓的研究。 | |||
| M31176
|
Recombinant Human CD40L Protein (E. coli) | 重组人CD40L蛋白 (E. coli) | Cytokines and Growth Factors |
| CD40 Ligand; CD154; TRAP | |||
| CD40 Ligand (CD40L/CD154/TRAP) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. Recombinant Human CD40 Ligand is produced by E.coli expression system and the target gene encoding Met113-Leu261 is expressed. | |||
| M39205 | Procyanidin B2 3,3'-di-O-gallate | Procyanidin B2 3,3'-di-O-gallate | Notch |
| Procyanidin B2, 3,3'-di-O-gallate 是一种活性成分。Procyanidin B2, 3,3'-di-O-gallate 可以从葡萄籽提取物 (GSE) 原花青素混合物中分离出来。 | |||
| M41616 | Batracylin | Batracylin | Topoisomerase |
| Batracylin (NSC320846) 是一种有效的 DNA 拓扑异构酶 I (DNA Topoisomerases I) 和 DNA 拓扑异构酶 II (DNA Topoisomerases I) 抑制剂。 | |||
| M44823 | Cyanidin 3-sophoroside chloride | 氯化矢车菊素-3-O-槐糖苷 | Others |
| Cyanidin 3-sophoroside chloride 是一种有效的非竞争性可逆 Polyphenol oxidase(PPO)抑制剂。 | |||
| M51387 | Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 | Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 | Others |
| Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) 是一种有生物活性的肽。 | |||
| M55299
|
Recombinant Human FLT3L (HEK293, C-6His) | 重组人FLT3L (HEK293, C-6His) | Cytokines and Growth Factors |
| Fms-like Tyrosine Kinase 3 Ligand | |||
| Fms-like Tyrosine Kinase 3 Ligand (FLT3L，FMS样胰激酶3配体) is a hematopoietic four helical bundle cytokine. Flt‑3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts. | |||
| M55883 | VMY-1-103 | VMY-1-103 | Caspase |
| VMY-1-103 是细胞周期蛋白/细胞周期蛋白依赖性激酶复合物 (cyclin/Cdk complex) 的抑制剂，可以在 G1 期阻滞细胞周期。VMY-1-103 可降低线粒体膜电位，诱导 p53 磷酸化和 PARP 裂解，激活 caspase-3，从而诱导前列腺癌细胞 LNCaP 凋亡 (apoptosis)。 | |||
| M58590
|
Recombinant Mouse Granzyme B (HEK293, C-6His) | 重组小鼠Granzyme B (HEK293, C-6His)；颗粒酶B(GZMB)重组蛋白 | Cytokines and Growth Factors |
| Gzmb | |||
| Granzyme B (GZMB) is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. | |||
