找到约 28 条 “CA inhibitor 1” 相关结果 （用时 0.112 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2497
|
Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1是一种组织蛋白酶(L，L2，S，K，B)的抑制剂，pIC50分别为7.9，6.7，6.0，5.5，5.2。 | |||
| M29336 | CA inhibitor 1 | CA inhibitor 1 | HIV Protease |
| GS-6207 analog | |||
| CA inhibitor 1 (GS-6207 analog) 是一种有效的 HIV 衣壳抑制剂，可用于抑制 HIV。 | |||
| M41182 | HIV-1 capsid inhibitor 1 | HIV-1 capsid inhibitor 1 | Anti-infection |
| HIV-1 capsid inhibitor 1 是一种有效的 HIV-1 Capsid 抑制剂，EC50 值为 3.13 µM。 | |||
| M42296 | Carbonic anhydrase inhibitor 15 | Carbonic anhydrase inhibitor 15 | Carbonic Anhydrase |
| Carbonic anhydrase inhibitor 15 是一种碳酸酐酶 (carbonic anhydrase) 抑制剂(Ki: 对 hCA II 为 8.5 nM)。 | |||
M45280
|
Casein Kinase inhibitor A51 | Casein Kinase inhibitor A51 | Casein Kinase |
| Casein Kinase inhibitor A51是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，能可诱导白血病细胞凋亡 (apoptosis)，可用于白血病的相关研究。 | |||
| M6651 | Damnacanthal | 丹宁卡；丹拿堪索 | Others |
| Damnacanthal is a potent, selective p56 lck inhibitor; also LIMK1/2 inhibitor. | |||
| M7731 | CHIC-35 | CHIC-35 | Others |
| CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. | |||
| M7934
|
MDL 28170 | MDL 28170 | Gamma-secretase/Beta-secretase |
| Calpain Inhibitor III | |||
| MDL-28170 (Calpain Inhibitor III) 是一种有效的、选择性的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可穿过血脑屏障。MDL-28170 还能阻断γ-secretase。 | |||
| M8757 | TASIN-1 hydrochloride | TASIN-1 hydrochloride | Others |
| TASIN-1 (Truncated APC Selective INhibitor-1) targets EBP- (Emopamil-binding protein; D8-D7 sterol isomerase) dependent cholesterol biosynthesis and selectively induces cellular cholesterol depletion and apoptotic death in human colorectal cancer (CRC). | |||
| M8839 | U-74389G | U-74389G | Others |
| Free radical lipid peroxidation inhibitor in cultured brain cells, monocytic THP1 cells, and LLC-PK1 cell layers. | |||
| M20388 | AC480 (BMS-599626) | AC480 (BMS-599626) | EGFR/HER2 |
| AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1. | |||
| M20458 | Tabersonine hydrochloride | Tabersonine hydrochloride | Amyloid |
| Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1?42) aggregation and toxicity. | |||
| M20575 | Lucanthone | Lucanthone | Autophagy |
| Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1. | |||
| M20662 | Demecarium Bromide | Demecarium Bromide | Others |
| BC-48 | |||
| Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. | |||
| M20775 | SEC inhibitor KL-1 | SEC inhibitor KL-1 | Others |
| KL-1 | |||
| SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | |||
| M20776 | cis-Resveratrol | cis-Resveratrol | Keap1-Nrf2 |
| cis-RESV, cRes, (Z)-Resveratrol | |||
| cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. | |||
| M20783 | Tenofovir alafenamide hemifumarate | Tenofovir alafenamide hemifumarate | Reverse Transcriptase |
| TAF hemifumarate, GS-7340 hemifumarate | |||
| Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. | |||
| M20862 | BCH | BCH | Others |
| 2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1 | |||
| BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells. | |||
| M20864 | L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium | Histone demethylase |
| (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG | |||
| L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively. | |||
| M20881 | 2-cyano-Pyrimidine | 2-cyano-Pyrimidine | Others |
| 2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. | |||
| M21208
|
BCATc Inhibitor 2 | BCATc Inhibitor 2 | Others |
| BCATc Inhibitor 2 是一种磺酰肼，可抑制BCATc，对大鼠的IC50s为0.2 µM。它对BCATm有15倍的选择性。它还被用来阻止钙流入神经元，抑制谷氨酸摄取后的IC50为4.8μM，并在体内大鼠神经退行性模型中显示出神经保护的功效。 | |||
| M28912 | (Rac)-Calpain Inhibitor XII | (Rac)-Calpain Inhibitor XII | Proteasome |
| (Rac)-Calpain Inhibitor XII 是可逆的，选择性的钙蛋白酶 I (calpain I; μ-calpain) 抑制剂，Ki 值为 19 nM。(Rac)-Calpain Inhibitor XII 对钙蛋白酶 II (calpain II; m-calpain; Ki=120 nM) 和组织蛋白酶 B (cathepsin B; Ki=750 nM) 具有较低的亲和力。 | |||
| M41594 | CaMKP inhibitor sodium | CaMKP inhibitor sodium | ROCK |
| CaMKP inhibitor sodium是选择性的 ROCK1 抑制剂，IC50 值为14 nM。 | |||
| M42905 | Cathepsin Inhibitor 3 | Cathepsin Inhibitor 3 | Others |
| Cathepsin Inhibitor 3 是化合物 [18F]2k 放射性合成中的非放射性中间体，对组织蛋白酶 S 具有选择性。 | |||
| M45288 | Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 | Casein Kinase |
| Casein Kinase inhibitor A86是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，同时还能抑制 CDK7 (TFIIH) 和 CDK9 (P-TEFb)。此外，Casein Kinase inhibitor A86 也可诱导白血病细胞凋亡 (apoptosis)，可用于白血病的相关研究。 | |||
| M54029 | Calcineurin autoinhibitory peptide | Calcineurin autoinhibitory peptide | Phosphatase |
| Calcineurin autoinhibitory peptide 是一种选择性的 Ca2+/ 钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)的抑制剂，IC50 值大约为 10 μM。 | |||
| M54866
|
Recombinant Human USP14 (E.coli, N-6His) | 重组人USP14 (E.coli, N-6His) | Cytokines and Growth Factors |
| Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14 | |||
| USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. | |||
| M55333
|
Recombinant Mouse GDF15 (HEK293, N-8His-Flag) | 重组小鼠GDF15 (HEK293, N-8His-Flag) | Cytokines and Growth Factors |
| Growth Differentiation Factor 15; Macrophage inhibitory cytokine 1; MIC-1 | |||
| Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenitors and introduced as a putative placental mediator of embryonic development. | |||
