找到约 9 条 “Bromodomain IN-2” 相关结果 （用时 0.195 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M41642 | Bromodomain IN-2 | Bromodomain IN-2 | Epigenetic Reader Domain |
| BD-IN-1 是一种泛溴结构域 (bromodomain (BD)) 抑制剂，对BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 的 KD 值分别为 250、420、130、430、67、240、970 nM。 | |||
| M41644 | Bromodomain inhibitor-12 | Bromodomain inhibitor-12 | Epigenetic Reader Domain |
| Bromodomain inhibitor-12 是一种 bromodomain 抑制剂，可用于自身免疫性和炎症类疾病的研究。 | |||
M25395
|
GSK1379725A | GSK1379725A | Epigenetic Reader Domain |
| AU1; AU-1 | |||
| GSK1379725A（AU1）是首个选择性的BPTF（Bromodomain PHD Finger Transcription Factor）配体，Kd值为2.8uM，对Brd4无结合活性。 | |||
| M4909
|
GSK2801 | GSK2801 | Epigenetic Reader Domain |
| GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively. | |||
| M8467 | OF-1 | OF-1 | Others |
| OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. | |||
| M10822
|
GNE-781 | GNE-781 | Epigenetic Reader Domain |
| GNE-781 (compound 19) 是一种高效的、口服活性的、选择性的 bromodomain 抑制剂对cyclic adenosine monophosphate response element binding protein (CBP) 的IC50值为0.94 nM (in TR-FRET assay)。GNE-781 还抑制 BRET 和 BRD4(1)，IC50分别为6.2 nM和5100 nM。 GNE-781 具有抗肿瘤活性。 | |||
| M20549 | GSK 5959 | GSK 5959 | Epigenetic Reader Domain |
| GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. | |||
| M20613
|
PF-CBP1 HCl | PF-CBP1 HCl | Epigenetic Reader Domain |
| PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. | |||
| M56039 | BET bromodomain inhibitor 1 | BET bromodomain inhibitor 1 | Epigenetic Reader Domain |
| BET bromodomain inhibitor 1 是一种具有口服活性的，选择性 BET 溴结构域抑制剂，对 BRD4 的 IC50 为 2.6 nM。 | |||
