找到约 6 条 “Aldosterone” 相关结果 （用时 0.108 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M7617
|
Aldosterone | 醛固酮 | Metabolite/Endogenous Metabolite |
| Aldosterone（醛固酮）是一种盐皮质激素。在动物模型中，其主要功能是调节体内的钠-钾代谢、维持血压稳定和调节酸碱平衡。醛固酮可通过作用于肾脏的远曲小管和集合管，增加钠离子和水的重吸收，同时促进钾离子的分泌。在细胞水平上，Aldosterone 的活性依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。 | |||
| M3256
|
Eplerenone | 依普利酮 | Others |
| Epoxymexrenone | |||
| Eplerenone (Epoxymexrenone，依普利酮) 是一种选择性，竞争性，具有口服活性的醛固酮 (aldosterone) 拮抗剂，IC50 为 138 nM，结构中包含螺环基团，对孕酮，雄激素，雌激素和糖皮质激素受体的亲和力低。Eplerenone 可用于高血压和心肌梗死后的心力衰竭的研究。 | |||
| M5786
|
Metyrapone | 美替拉酮；甲吡酮 | Metabolite/Endogenous Metabolite |
| Metapirone; Su-4885 | |||
| Metyrapone (Metapirone) 是一种有效且具有口服活性的 11β-羟化酶 (11β-hydroxylase) 抑制剂，可抑制醛固酮 (aldosterone) 的产生，也是一种细胞自噬 (autophagy) 激活剂。Metyrapone (Metapirone) 抑制P450介导的ω/ω-1羟化酶活性和CYP11B1。 | |||
| M20441
|
Efonidipine | Efonidipine | Calcium Channel |
| NZ-105 | |||
| Efonidipine is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal. | |||
| M58552
|
Recombinant Human Adrenomedullin Protein (HEK293, N-hFc) | 重组人Adrenomedullin 蛋白 (HEK293, N-hFc)；人肾上腺髓质素(ADM)重组蛋白 | Cytokines and Growth Factors |
| rhADM | |||
| Adrenomedullin is a a hypotensive peptide and has 1 intramolecular disulfide bond. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. | |||
| M58786
|
Recombinant Human MCR (E.Coli) | 重组人MCR (E.Coli) | Target Proteins |
| Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. | |||
