找到约 8 条 “ALK2-IN-2” 相关结果 （用时 0.477 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M14942 | ALK2-IN-2 | ALK2-IN-2 | TGF-β Receptor |
| ALK2-IN-2 是一种有效的、选择性的活化素受体样激酶 2 (ALK2) 抑制剂，IC50 值为 9 nM，对 ALK2 的抑制作用是 ALK3 的 700 倍。 | |||
M55622
|
Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | 重组人BMPRIA/ALK-3/CD292 蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | |||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | |||
M2075
|
LDK378 | 色瑞替尼；塞瑞替尼 | ALK |
| Ceritinib | |||
| Ceritinib (LDK378) 是一种选择性，具有口服活性的 ALK 酪氨酸激酶抑制剂，IC50 为0.2 nM。Ceritinib (LDK378) 还可抑制 IGF-1R，InsR和STK22D，IC50 值分别为 8、7和23 nM。Ceritinib可用于ALK阳性的非小细胞肺癌（NSCLC）的研究。 | |||
| M20633 | TP0427736 HCl | TP0427736 HCl | Src-bcr-Abl |
| TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. | |||
| M43471 | ALK2-IN-5 | ALK2-IN-5 | ALK |
| ALK2-IN-5 是吡唑并嘧啶化合物，是一种 ALK2 抑制剂。 | |||
| M49468
|
Neladalkib | 奈拉达基；尼拉达基 | ALK |
| NVL-655; ALK-IN-27 | |||
| Neladalkib (NVL-655, ALK-IN-27) 是一种新型的，脑部渗透性的，选择性ALK抑制剂，具有抗肿瘤活性。对于 Ba/F3 CLIP1-LTK 细胞，NVL-655 (ALK-IN-27) 的 IC50 为 2.7 nM。Neladalkib (NVL-655, ALK-IN-27) 可用于ALK阳性非小细胞肺癌（NSCLC）的相关研究。 | |||
| M55234 | NVL-655 TFA | NVL-655 TFA | ALK |
| ALK-IN-27 TFA | |||
| NVL-655 (ALK-IN-27) TFA 是一种新型的，脑部渗透性的，选择性ALK抑制剂，具有抗肿瘤活性。对于 Ba/F3 CLIP1-LTK 细胞，NVL-655 (ALK-IN-27) TFA 的 IC50 为 2.7 nM。可用于ALK阳性非小细胞肺癌（NSCLC）的相关研究。 | |||
| M57183
|
ALK inhibitor 2 | ALK inhibitor 2 | ALK |
| ALK inhibitor 2 是一种有效的，嘧啶类 ALK 抑制剂。ALK inhibitor 2 是有效的睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2; IC50=37 nM) 和粘着斑激酶 (FAK; IC50=5 nM) 抑制剂。 | |||
