Sotatercept-csrk 是第一个获得FDA批准的激活素信号抑制剂，它通过改善促增殖和抗增殖信号传导之间的平衡来调节PAH的血管细胞增殖。Sotatercept是一种靶向ACVR2A的融合蛋白，可恢复肺动脉内生长途径的平衡。
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| Recombinant Human B2M Protein (Mammalian, C-6His)
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| Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
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蛋白质研究