RSV604 (A-60444) 是一种具有细胞渗透性的、无细胞毒性的呼吸道合胞病毒 (RSV) 复制的抑制剂。RSV604 靶向呼吸道合胞病毒(RSV)的核蛋白(N)的Kd 值为 1.6 ± 0.4 μM。
别名:A-60444; RSV-604
RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM). Although RSV604 displays host-dependent potency against RSV cellular replication (EC50 = 2 μM/HeLa, 1.8 μM/HEp-2, >50 μM/BHK-21 based on cellular viral F protein level 72 hrs post RSV A2 infection) and release (by >1,000,000-fold/HeLa vs. no effect/BHK-21 72 hrs post infection; [RSV604] = EC90), complete loss of infectivity of released RSV from RSV604-treated cells is observed in both HeLa and BHK-21 cultures. RSV604 is also active against bovine RSV, but inactive toward mouse pneumonia virus, human metapneumovirus or parainfluenza virus types 1 &3 (PIV1 &PIV3).
Adv Healthc Mater. 2023 Aug 2;e2301325.
J Control Release. 2022 Dec 15;353:675-684.
Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia
分子量 | 388.39 |
分子式 | C22H17FN4O2 |
CAS号 | 676128-63-5 |
溶解性(25°C) | DMSO 60 mg/mL |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前,需考虑其在不同溶剂中的溶解度限制。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.5747 mL | 12.8737 mL | 25.7473 mL |
5 mM | 0.5149 mL | 2.5747 mL | 5.1495 mL |
10 mM | 0.2575 mL | 1.2874 mL | 2.5747 mL |
小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
动物 A的Km系数 |
例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。
[2] SreeRupa Challa, et al. Mechanism of action for respiratory syncytial virus inhibitor RSV604
[4] James D Nokes, et al. New strategies for control of respiratory syncytial virus infection
[5] Joanna Chapman, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication
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