重组大鼠干扰素γ (IFN-γ， Rat)又称II型干扰素或免疫干扰素，是一种主要由t淋巴细胞和自然杀伤细胞产生的细胞因子，可用于构建斑秃动物模型。
别名：rRtIFN-γ; IFN-γ, Rat (CHO-expressed)
重组大鼠干扰素γ (IFN-γ， Rat)又称II型干扰素或免疫干扰素，是一种主要由t淋巴细胞和自然杀伤细胞产生的细胞因子。IFN-γ信号通路具有多种生物学功能，主要与宿主防御和免疫调节有关，包括抗病毒和抗菌防御、细胞凋亡、炎症以及先天和获得性免疫。虽然IFN-γ诱导的炎症级联反应可诱导多种免疫相关细胞类型，如巨噬细胞、自然杀伤(NK)细胞和细胞毒性T淋巴细胞(CTLs)，但IFN-γ也参与对NK细胞和CTL反应的抵抗以及多种癌症的免疫逃逸。成熟的IFN-γ以非共价连接的同二聚体的形式存在。它与小鼠IFN-γ序列一致性高(86%)。IFN-γ最初的特征是基于其抗病毒活性。该蛋白还发挥抗增殖、免疫调节和促炎活性，因此在宿主防御机制中很重要。IFN-γ诱导细胞因子的产生，上调I类和II类MHC抗原、Fc受体和白细胞粘附分子的表达。它调节巨噬细胞效应器功能，影响同型转换和增强B细胞的免疫球蛋白分泌。此外，IFN-γ增强TH1细胞扩增，可能是TH1细胞分化所必需的。
| 溶解性（25°C） | Water Saline PBS |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究