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Recombinant Rat CXCL1/CINC-1 Protein (E. coli) 重组大鼠CXCL1/CINC-1蛋白 (E. coli)

目录号 M22457 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


大鼠 CXCL1,也称为 CINC-1,属于 CXC 趋化因子家族。CXCL1 可作为破骨细胞前体的趋化剂。CXCL1 还可能通过其对感觉神经元的直接作用而具有重要的促伤害感受作用,并且可能诱导涉及蛋白质合成的长期变化。

Recombinant Rat CXCL1/CINC-1 Protein (E. coli)结构式
规格 价格 库存状态
5ug ¥ 1575 中国库存现货
100ug ¥ 8370 中国库存现货
其他规格数量报价?

质量标准及产品资料
生物活性

大鼠 CXCL1,也称为 CINC-1,属于 CXC 趋化因子家族。CXCL1 可作为破骨细胞前体的趋化剂。CXCL1 还可能通过其对感觉神经元的直接作用而具有重要的促伤害感受作用,并且可能诱导涉及蛋白质合成的长期变化。CXCL1 是一种有效的中性粒细胞化学引诱剂,在血管生成和炎症中具有公认的作用。CXCL1 通过 CXCR2 发挥作用,通过 HB-EGF 的蛋白水解切割来反式激活 EGFR,从而导致 MAPK 信号的激活和上皮性卵巢癌 (EOC) 细胞增殖的增加。它可能通过在肿瘤发生早期加强衰老来限制肿瘤生长。因此,CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用,并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。


重组大鼠 Cxcl1 由 72 个氨基酸组成,预测分子量为 7.9 kDa。

剂型描述:从无菌 20 mM Tris、500 mM NaCl、pH 8 中冻干。

化学性质
储存条件 Stable for up to twelve months from date of receipt at -20℃ to -80℃
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Yingfei Wang, et al. J Neurochem. Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1

[2] Casey M Calkins, et al. J Endotoxin Res. IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia

[3] K Takaishi, et al. J Biochem. Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of IkappaBalpha

[4] F Shibata, et al. Cytokine. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation

[5] F Shibata, et al. Eur J Biochem. Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3

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