大鼠 CXCL1,也称为 CINC-1,属于 CXC 趋化因子家族。CXCL1 可作为破骨细胞前体的趋化剂。CXCL1 还可能通过其对感觉神经元的直接作用而具有重要的促伤害感受作用,并且可能诱导涉及蛋白质合成的长期变化。
大鼠 CXCL1,也称为 CINC-1,属于 CXC 趋化因子家族。CXCL1 可作为破骨细胞前体的趋化剂。CXCL1 还可能通过其对感觉神经元的直接作用而具有重要的促伤害感受作用,并且可能诱导涉及蛋白质合成的长期变化。CXCL1 是一种有效的中性粒细胞化学引诱剂,在血管生成和炎症中具有公认的作用。CXCL1 通过 CXCR2 发挥作用,通过 HB-EGF 的蛋白水解切割来反式激活 EGFR,从而导致 MAPK 信号的激活和上皮性卵巢癌 (EOC) 细胞增殖的增加。它可能通过在肿瘤发生早期加强衰老来限制肿瘤生长。因此,CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用,并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。
重组大鼠 Cxcl1 由 72 个氨基酸组成,预测分子量为 7.9 kDa。
剂型描述:从无菌 20 mM Tris、500 mM NaCl、pH 8 中冻干。
储存条件 | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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