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Recombinant Murine GM-CSF Protein (HEK293, C-His) 重组小鼠GM-CSF蛋白 (HEK293, C-His)

目录号 M22482 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组小鼠GM-CSF蛋白是一种造血生长因子,能促进中性粒细胞和巨噬细胞的发育,促进早期红系巨核细胞和嗜酸性祖细胞的增殖和发育。

Recombinant Murine GM-CSF Protein (HEK293, C-His)结构式
规格 价格 库存状态
50ug ¥ 4000 中国库存现货
100ug ¥ 6200 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >90%, Endotoxin < 1EU/µg
  • COA
  • MSDS
生物活性

重组小鼠GM-CSF蛋白是一种造血生长因子,能促进中性粒细胞和巨噬细胞的发育,促进早期红系巨核细胞和嗜酸性祖细胞的增殖和发育。GM-CSF由内皮细胞、单核细胞、成纤维细胞和T淋巴细胞产生。GM-CSF抑制中性粒细胞的迁移,增强成熟终末细胞的功能活性。人和小鼠分子具有物种特异性。

以剂量依赖性刺激小鼠FDC-P1细胞增殖ED50为≤0.05 ng/ml,对应的特异性活性≥2×107 IU/mg。


蛋白序列:DNA 序列编码小鼠 GM-CSF(NP_034099.2)表达带有 His 标签在 C 末端

分子量:重组小鼠 GM-CSF蛋白 包含 130 个氨基酸,预测理论分子量为 15kD


化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS at 100 μg/ml
储存条件 Stored at ≤ -20°C, stable for one year after receipt
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Pravin Yeapuri, et al. J Control Release. Development of an extended half-life GM-CSF fusion protein for Parkinson's disease

[2] Michael Dougan, et al. Immunity. GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

[3] E Reali, et al. Vaccine. Comparative studies of Avipox-GM-CSF versus recombinant GM-CSF protein as immune adjuvants with different vaccine platforms

[4] J C Schuh, et al. Toxicol Pathol. Development of a recombinant growth factor and fusion protein: lessons from GM-CSF

[5] C Wiltschke, et al. Immunobiology. Murine recombinant GM-CSF-driven rat bone marrow cell differentiation and factors suppressing cell proliferation

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