Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia–reperfusion injury.
别名：Neutrophil gelatinase-associated lipocalin; LCN2
Lipocalin-2（脂联素-2）又称中性粒细胞明胶酶相关脂联素（NGAL），是脂联素超家族的一种分泌性蛋白。脂联素-2含有一个信号肽，使其能够被分泌并通过二硫键与基质金属蛋白酶-9（MMP-9）形成复合物。与其他脂联素家族成员相似，Lipocalin-2参与了不同的细胞过程，包括运输小的疏水分子，保护MMP-9不被蛋白酶降解，以及细胞信号传导。此外，Lipocalin-2可以通过细胞表面受体与细菌的铁质紧密结合，可能通过封存铁质、调节先天免疫和保护肾脏上皮细胞免受缺血再灌注损伤而成为一种有效的杀菌剂。
Accession: P11672
APMol Mass: 20-28 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 8% Trehalose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH6.5.
| 性状 | Lyophilized powder |
| 溶解性（25°C） | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究