重组小鼠IGF-I蛋白属于 IGF 肽家族,该家族还包括 IGF-II 和胰岛素。IGF-I的基因表达主要受生长激素调控,IGF-I通过跨膜酪氨酸受体(IGF Receptors)发出信号来发挥其功能。通过使用 FDC-P1 细胞的细胞增殖测定法测量的ED50 < 10.0 ng/ml,对应于 > 1.0 × 105units/mg 的比活性。
别名:Insulin-like Growth Factor I
重组小鼠IGF-I蛋白属于 IGF 肽家族,该家族还包括 IGF-II 和胰岛素。IGF-I的基因表达主要受生长激素调控,IGF-I通过跨膜酪氨酸受体(IGF Receptors)发出信号来发挥其功能。IGFBP 可能通过与 IGF 受体竞争来抑制 IGF 的作用。IGF-I 在产后和成年动物中很活跃,对体细胞生长至关重要。
通过使用 FDC-P1 细胞的细胞增殖测定法测量的ED50 < 10.0 ng/ml,对应于 > 1.0 × 105units/mg 的比活性。
蛋白编号: # P05017
表观分子量: ~7.8 kDa,在还原条件下的 SDS-PAGE 上。
剂型描述:从 0.2 μm 过滤的 PBS 溶液中冻干。
溶解性(25°C) | Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
储存条件 | Stable for up to 6 months at lower than -70°C |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
[4] C Warburton, et al. Receptor. Mouse models of IGF-I deficiency generated by gene targeting
[5] G L Wong, et al. J Bone Miner Res. IGF-I production by mouse osteoblasts
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