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Recombinant Mouse IGF-I Protein (E. coli) 重组小鼠IGF-I蛋白 (E. coli)

目录号 M21721 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组小鼠IGF-I蛋白属于 IGF 肽家族,该家族还包括 IGF-II 和胰岛素。IGF-I的基因表达主要受生长激素调控,IGF-I通过跨膜酪氨酸受体(IGF Receptors)发出信号来发挥其功能。通过使用 FDC-P1 细胞的细胞增殖测定法测量的ED50 < 10.0 ng/ml,对应于 > 1.0 × 105units/mg 的比活性。

Recombinant Mouse IGF-I Protein (E. coli)结构式

别名:Insulin-like Growth Factor I

规格 价格 库存状态
10ug ¥ 1200 中国库存现货
50ug ¥ 1880 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
生物活性

重组小鼠IGF-I蛋白属于 IGF 肽家族,该家族还包括 IGF-II 和胰岛素。IGF-I的基因表达主要受生长激素调控,IGF-I通过跨膜酪氨酸受体(IGF Receptors)发出信号来发挥其功能。IGFBP 可能通过与 IGF 受体竞争来抑制 IGF 的作用。IGF-I 在产后和成年动物中很活跃,对体细胞生长至关重要。

通过使用 FDC-P1 细胞的细胞增殖测定法测量的ED50 < 10.0 ng/ml,对应于 > 1.0 × 105units/mg 的比活性。

蛋白编号: # P05017

表观分子量: ~7.8 kDa,在还原条件下的 SDS-PAGE 上。

剂型描述:从 0.2 μm 过滤的 PBS 溶液中冻干。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml.
储存条件 Stable for up to 6 months at lower than -70°C
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Esteban J Fiore, et al. Stem Cells Dev. Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice

[2] John L Fowlkes, et al. J Bone Miner Res. Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model

[3] R Sandstrm, et al. Eur J Clin Invest. The effect of recombinant human IGF-I on protein metabolism in post-operative patients without nutrition compared to effects in experimental animals

[4] C Warburton, et al. Receptor. Mouse models of IGF-I deficiency generated by gene targeting

[5] G L Wong, et al. J Bone Miner Res. IGF-I production by mouse osteoblasts

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