胶质神经营养因子，又称GDNF和ATF-1，是一种属于TGF-β家族的神经营养因子。ED50 < 8.0 μg/ml，在使用C6细胞的生物测定中测量。Accession # P48540。
别名：Glial-Derived Neurotrophic Facto; ATF-1
种属：Mouse
表达系统：CHO
内毒素：通过凝胶凝固法，< 0.2 EU/μg的蛋白质
纯度：> 经SDS-PAGE分析，大于95%，> 通过HPLC分析，大于95%
表观分子量：17~22 kDa，在还原条件下的SDS-PAGE上
存储及稳定性：本品收到后，在低于-70°C的环境下可保持长达6个月的稳定性。重组后，本品在4°C下应可稳定1周，或在-20°C下可稳定3个月。对于长期储存，建议加入载体蛋白（如0.1% BSA）。避免重复冻融循环。
生物活性： 它在中枢神经系统（CNS）和非CNS组织中都有表达。GDNF通过一个由RET和四个GFRα受体中的一个组成的受体系统发出信号。它促进多巴胺能神经元的生存和分化，并增加其高亲和力的多巴胺摄取。在小鼠帕金森病模型中，GDNF已被证明能改善运动迟缓、僵硬和姿势不稳。GDNF还被证明可以调节肾脏发育、精子生成和影响酒精消费。
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[5] Jun Kawanokuchi, et al. J Neuroimmunol. Production and functions of IL-17 in microglia
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蛋白质研究