心肌营养因子-1 (CT-1)是细胞因子家族的成员之一,该家族还包括IL-6、IL-11、白血病抑制因子(LIF)、肿瘤抑制素M (OSM)和睫状神经营养因子(CNTF)。蛋白构造:CT-1 (Ser2-Ala203),Accession # Q60753-1。
别名:CTF1; CT-1
种属:Mouse
表达系统:HEK 293
纯度:SDS-PAGE分析,> 95%
内毒素:凝胶凝血法测定蛋白质< 0.2 EU/μg
表观分子量:22~ 27kda,还原条件下在SDS-PAGE上
存储及稳定性:在接收后,该产品在低于-70°C的环境下保持稳定长达6个月。重组后,产品应在4°C下稳定1周或在-20°C下稳定3个月。为了长期保存,建议添加载体蛋白(如0.1% BSA)。避免反复的冻融循环。
生物活性:TF-1细胞剂量依赖性增殖测定小鼠心肌营养因子-1 EC50值≤1.25 ng/ml,比活性≥0.8 × 106单位/mg。CT-1与高血压、心肌梗死、心脏瓣膜病和充血性心力衰竭等多种心脏病的病理生理相关。该蛋白通过与糖蛋白130 (gp130)/白血病抑制因子受体β (LIFR)异二聚体相互作用发挥其细胞效应。CT-1激活心肌细胞磷脂酰肌醇3激酶(PI-3激酶)并增强转录因子NF-κB DNA结合活性。CT-1在心脏、骨骼肌、前列腺和卵巢高表达,在肺、肾、胰腺、胸腺、睾丸和小肠低表达。
溶解性(25°C) | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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