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Recombinant Human VWF Protein (CHO, His Tag) 重组人VWF蛋白 (CHO, His Tag)

目录号 M25480 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury.

Recombinant Human VWF Protein (CHO, His Tag)结构式

别名:Von Willebrand Factor; rhvwf

规格 价格 库存状态
100ug ¥ 9000 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >75%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
生物活性

Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.

A DNA sequence encoding the pro form of human Von Willebrand factor (AAB59458.1) (Met1-Lys2813) was expressed with a C-terminal polyhistidine tag.

The recombinant human VWF consists of 2802 amino acids after removal of the signal peptide and has a predicted molecular mass of 308 kDa.


Endotoxin: < 1.0 EU/μg

Lyophilized from sterile PBS, pH 7.4.

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
储存条件 Stable for up to twelve months from date of receipt at -20℃ to -80℃
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Juan A De Pablo-Moreno, et al. Int J Mol Sci. The Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V

[2] Ruchika Sharma, et al. Hematology Am Soc Hematol Educ Program. New advances in the diagnosis of von Willebrand disease

[3] Meaghan E Colling, et al. Clin Appl Thromb Hemost. In Vitro Assessment of von Willebrand Factor in Cryoprecipitate, Antihemophilic Factor/VWF Complex (Human), and Recombinant von Willebrand Factor

[4] Giancarlo Castaman, et al. Eur J Haematol. Pregnancy and delivery in women with von Willebrand disease

[5] Eva-Maria Muchitsch, et al. Semin Thromb Hemost. Preclinical testing of human recombinant von Willebrand factor: ADAMTS13 cleavage capacity in animals as criterion for species suitability

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