重组人TGF-α又称肉瘤生长因子、TGF- I型和ETGF,是EGF家族细胞因子的一员。
别名:Human Transforming Growth Factor-alpha
Recombinant Human TGF-α, also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. The biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF bind to the same receptor. When TGF-α binds to EGFR it can initiate multiple cell proliferation events.
ED50 < 0.2ng/ml, measured by Cell Proliferation Assay using BALB/c 3T3 cells, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Lyophilized recombinant Human TGF-α remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TGF-α should be stable up to 1 week at 4°C or up to 3 months at -20°C.
溶解性(25°C) | Reconstituted in ddH2O or PBS at 100 μg/mL |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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