重组人Neuregulin-1 beta由大肠杆菌表达系统产生，目的基因编码Ser2-Lys246被表达。Accession #: AAA58639.1。
别名：Pro-neuregulin-1;Neuregulin-1 beta 1
种属：Human
表达系统：E.coli
纯度：通过减少SDS-PAGE确定大于85%
内毒素：经LAL测定，小于0.001 ng/ug (0.01 EU/ug)
存储及稳定性：冻干蛋白应在< -20°C保存，但在室温下可保存3周。重组蛋白溶液可在4-7℃下保存2-7天。重组样品的等分液在< -20°C下稳定3个月。
生物活性：NRG1 (Pro-neuregulin-1, neuregulin-1 beta 1)是一种单通路的I型膜蛋白，属于neuregulin家族，包含1个egf样结构域和1个Ig-like c2型(免疫球蛋白样)结构域。ERBB3和ERBB4酪氨酸激酶受体的直接配体。该蛋白同时招募ERBB1和ERBB2共受体，导致配体刺激的酪氨酸磷酸化和ERBB受体的激活。多种亚型具有多种功能，如诱导上皮细胞、胶质细胞、神经元细胞和骨骼肌细胞的生长和分化;神经肌肉连接形成过程中诱导突触囊泡内乙酰胆碱受体表达刺激乳腺小叶肺泡出芽和泌乳诱导乳腺肿瘤细胞分化刺激雪旺细胞增殖;与心肌发育有关，如发育中的心脏小梁形成。Isoform 10可能在运动神经元和感觉神经元的发育中发挥作用。
| 溶解性（25°C） | It is not recommended to reconstitute to a concentration less than 100 μg/ml. |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究