Lactoferrin (LTF,乳铁蛋白) 是外分泌液中的主要铁结合蛋白,通过螯合铁和破坏细菌膜而表现出多种抗菌作用。它可以防止生物膜形成,影响骨代谢,并影响腺病毒和乳头瘤病毒感染。
别名:Lactotransferrin; Kaliocin-1
Lactoferrin (LTF,乳铁蛋白) 是外分泌液中的主要铁结合蛋白,通过螯合铁和破坏细菌膜而表现出多种抗菌作用。它可以防止生物膜形成,影响骨代谢,并影响腺病毒和乳头瘤病毒感染。LTF 刺激 TLR4 信号传导通路,导致 NF-κ-B 激活和促炎细胞因子产生,同时干扰脂多糖刺激的 TLR4 信号传导。LTF还通过对成骨细胞发挥合成代谢、分化和抗凋亡作用来影响骨代谢,同时还抑制破骨细胞生成。
Measured by its ability to increase regulate the expression of TNF-α in THP-1 cells, the ED50 for this effect is 97 ng/mL, corresponding to a specific activity is 1.03×104 U/mg.
Recombinant Human Lactotransferrin/LTF expressed the target gene encoding Gly20-Lys711 with a 6His tag at the C-terminus.
Accession: AAH15822.1
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 90 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
性状 | Lyophilized powder |
溶解性(25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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