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Recombinant Human KRAS (G12D, E. coli, His) 重组人 KRAS 蛋白 (G12D, E. coli, His)

目录号 M11234 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人 KRAS 蛋白 (G12D, E. coli, His) 由大肠杆菌表达系统产生,N 末端用 6His 标签表达。

Recombinant Human KRAS (G12D, E. coli, His)结构式

别名:Recombinant Human KRAS G12D (E. coli, His)

规格 价格 库存状态
50ug ¥ 3960 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >90%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
生物活性

The KRAS gene provides instructions for making a protein called K-Ras, part of the RAS/MAPK pathway. The K-Ras protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. 


Accession #: P01116-2 

Molecular Weight: 23.8 kDa 

Endotoxin: ≤ 1 EU/μg 

Lyophilized from a 0.2 μm filtered solution in PBS.

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
储存条件 Stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Yongde Luo, et al. Gastroenterology. Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

[2] Callum P Rakhit, et al. Dis Model Mech. Early detection of pre-malignant lesions in a KRAS G12D-driven mouse lung cancer model by monitoring circulating free DNA

[3] Gal Cafri, et al. Nat Commun. Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

[4] Shanmin Zhao, et al. Cell Physiol Biochem. KRAS (G12D) cooperates with AML1/ETO to initiate a mouse model mimicking human acute myeloid leukemia

[5] Victoria A Appleman, et al. Mol Cancer Res. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling

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