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Recombinant Human IGF-I (E.coli, 67AA) 重组人IGF-1 (E.coli, 67AA)

目录号 M21631 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人胰岛素样生长因子 I (IGF-1) 结合 IGF-1R、IGF-2R 和胰岛素受体,并在细胞周期进程、细胞增殖和肿瘤进程中发挥关键作用。使用 MCF-7 人乳腺癌细胞在无血清细胞增殖试验中测量的 ED50 为 20-100 ng/ml。

Recombinant Human IGF-I (E.coli, 67AA)结构式

别名:Insulin-Like Growth Factor I; IGF1; Mecasermin

规格 价格 库存状态
10ug ¥ 855 中国库存现货
50ug ¥ 1125 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 0.5 EU/μg
  • COA
  • MSDS
生物活性

重组人胰岛素样生长因子 I (IGF-1) 结合 IGF-1R、IGF-2R 和胰岛素受体,并在细胞周期进程、细胞增殖和肿瘤进程中发挥关键作用。

使用 MCF-7 人乳腺癌细胞在无血清细胞增殖试验中测量的 ED50 为 20-100 ng/ml。

化学性质
分子量 7645.68
分子式 C331H512N94O101S7
CAS号 68562-41-4
溶解性(25°C) Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml
储存条件 Stored at ≤ -20°C, stable for one year after receipt
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前,需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.1308 mL 0.654 mL 1.3079 mL
5 mM 0.0262 mL 0.1308 mL 0.2616 mL
10 mM 0.0131 mL 0.0654 mL 0.1308 mL
不同实验动物依据体表面积的等效剂量转换表(参考来源于公开文献
小鼠 大鼠 豚鼠 仓鼠
重量 (kg) 0.02 0.15 1.8 0.4 0.08 10
体表面积 (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km 系数 3 6 12 8 5 20
动物 A (mg/kg) = 动物 B (mg/kg) ×  动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。

参考文献

[1] Philippe Backeljauw. Growth Horm IGF Res. Therapy with recombinant human IGF-1 for children with primary insulin-like growth factor-I deficiency

[2] Adda Grimberg, et al. Horm Res Paediatr. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

[3] George M Bright. Growth Horm IGF Res. Recombinant IGF-I: Past, present and future

[4] Kevin C J Yuen, et al. Growth Horm IGF Res. Impact of treatment with recombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults

[5] Ross G Clark. Horm Res. Recombinant human insulin-like growth factor I (IGF-I): risks and benefits of normalizing blood IGF-I concentrations

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