重组人胰岛素样生长因子 I (IGF-1) 结合 IGF-1R、IGF-2R 和胰岛素受体,并在细胞周期进程、细胞增殖和肿瘤进程中发挥关键作用。使用 MCF-7 人乳腺癌细胞在无血清细胞增殖试验中测量的 ED50 为 20-100 ng/ml。
别名:Insulin-Like Growth Factor I; IGF1; Mecasermin
重组人胰岛素样生长因子 I (IGF-1) 结合 IGF-1R、IGF-2R 和胰岛素受体,并在细胞周期进程、细胞增殖和肿瘤进程中发挥关键作用。
使用 MCF-7 人乳腺癌细胞在无血清细胞增殖试验中测量的 ED50 为 20-100 ng/ml。
分子量 | 7645.68 |
分子式 | C331H512N94O101S7 |
CAS号 | 68562-41-4 |
溶解性(25°C) | Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前,需考虑其在不同溶剂中的溶解度限制。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 0.1308 mL | 0.654 mL | 1.3079 mL |
5 mM | 0.0262 mL | 0.1308 mL | 0.2616 mL |
10 mM | 0.0131 mL | 0.0654 mL | 0.1308 mL |
小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
动物 A的Km系数 |
例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。
[3] George M Bright. Growth Horm IGF Res. Recombinant IGF-I: Past, present and future
其他相关的Recombinant Proteins产品 |
---|
Recombinant Mouse Lumican (Mammalian, C-6His)
Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. |
Recombinant Human Serpin A12 (E.coli, N-GST)
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. |
Recombinant Human B2M Protein (Mammalian, C-6His)
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. |
Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
产品仅供科学研究或药证申报的用途使用,不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号