重组人干扰素Alpha-2a由大肠杆菌表达系统生产。蛋白编号:P01563。ED50 < 0.1 ng/ml,通过使用TF-1细胞的细胞毒性试验测量,对应的特异性活性> 1.0 × 107 units/mg。
别名:Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A
种属:Human
表达系统:E.coli
纯度: 通过还原SDS-PAGE测定,大于95%
内毒素:经LAL测试,小于0.1 ng/µg(1 EU/µg)
表观分子量:16 KDa,还原条件
存储及稳定性:冻干的蛋白质应储存在<-20°C,尽管在室温下可稳定3周。重组的蛋白质溶液可在4-7°C储存2-7天。重组的样品等分在<-20°C下可稳定3个月。
生物活性:由白细胞产生的人类干扰素Alpha 2a(IFN-Alpha 2a)是干扰素家族的一个成员。IFN-α主要参与先天性免疫反应,以对抗广泛的病毒感染。IFN-alpha 2有三种酸性稳定形式(a,b,c),通过IFNAR2进行信号传递。IFN-alpha 2a与IFN-alpha 2b和2c分别有99.4%、98.8%的相同序列。IFN-alpha含有四个高度保守的半胱氨酸残基,形成两个二硫键,其中一个是生物活性所必需的。
溶解性(25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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