Histone deacetylase 8（HDAC8，HDACL1）是一种细胞核和细胞质蛋白质，属于组蛋白去乙酰化酶家族和 HD 1 型亚族，能通过影响细胞核中核心组蛋白的乙酰化状态参与转录调控。HDAC8 / HDACL1 在大多数组织中表达较弱，在心脏、大脑、肾脏和胰腺以及肝脏、肺脏、胎盘、前列腺和肾脏中的表达水平较高。HDAC8 / HDACL1 负责核心组蛋白（H2A、H2B、H3 和 H4）N 端赖氨酸残基的去乙酰化。
别名：Histone deacetylase 8
Histone deacetylase 8（HDAC8，HDACL1）是一种细胞核和细胞质蛋白质，属于组蛋白去乙酰化酶家族和 HD 1 型亚族，能通过影响细胞核中核心组蛋白的乙酰化状态参与转录调控。HDAC8 / HDACL1 在大多数组织中表达较弱。它在心脏、大脑、肾脏和胰腺以及肝脏、肺脏、胎盘、前列腺和肾脏中的表达水平较高。HDAC8 / HDACL1 负责核心组蛋白（H2A、H2B、H3 和 H4）N 端赖氨酸残基的去乙酰化。组蛋白去乙酰化为表观遗传抑制提供了一个标签，在转录调控、细胞周期进展和发育过程中发挥着重要作用。HDAC8通过形成大型多蛋白复合物发挥作用。HDAC8 / HDACL1 可能在平滑肌细胞收缩性中发挥作用。HDAC8 / HDACL1可能是使用选择性抑制剂进行神经母细胞瘤分化治疗的潜在药物靶点，可避免非特异性副作用。
内毒素 < 1 EU/µg
表观分子量: 68 kDa，还原条件
剂型描述：从无菌的 50mM Tris、100mM NaCl、0.5mM PMSF 和 10% 甘油pH 值为 8.0的溶液中冻干而成。
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究