肝素原结合 EGF 样生长因子 (HB-EGF) 是有丝分裂原 EGF 家族的成员。它在巨噬细胞、单核细胞、内皮细胞和肌肉细胞中表达。HB-EGF 信号通过 EGF 受体刺激平滑肌细胞、上皮细胞和角质形成细胞的增殖。ED50 < 0.75 ng/ml，使用 3T3 细胞在细胞增殖测定中测得。
别名：HEGFL; Heparin Binding EGF-like growth factor
原肝素结合EGF样生长因子（HB-EGF），也称为DTR、DTS和HEGFL，是EGF家族有丝分裂原的成员。它在巨噬细胞、单核细胞、内皮细胞和肌肉细胞中表达。HB-EGF通过EGF受体发出信号，刺激平滑肌细胞、上皮细胞和角质形成细胞的增殖。与EGF相比，HB-EGF以更高的亲和力与EGF受体结合，并被证明更易促有丝分裂，这可能是由于其与肝素和硫酸肝素蛋白聚糖结合的能力。HB-EGF也被报道为白喉毒素受体，介导结合毒素的内吞作用。HB-EGF已显示与NRD1、锌指和含有BTB结构域的蛋白16和BAG1相互作用。
ED50 < 0.75 ng/ml，使用 3T3 细胞在细胞增殖测定中测得。
Accession： # Q99075。
表观分子量：12～14kDa，在还原条件下进行SDS-PAGE分析
剂型描述：从 PBS 中的 0.2 µm 过滤浓缩溶液冻干。
| 溶解性（25°C） | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS to 100 μg/ml. |
| 储存条件 | Stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究