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Recombinant Human GPNMB (Mammalian, C-6His) 重组人GPNMB 蛋白 (Mammalian, C-6His)

目录号 M21638 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人GPNMB (糖蛋白非转移性黑色素瘤 B) 蛋白由哺乳动物表达系统产生,编码 Ala22-Pro486 的靶基因在 C 末端用 6His 标签表达。骨激活素是一种细胞内糖蛋白,属于 NMB/pMEL-17 家族,与细胞内体/溶酶体区室相关。

Recombinant Human GPNMB (Mammalian, C-6His)结构式

别名:Glycoprotein Non-Metastatic Melanoma Protein B

规格 价格 库存状态
10ug ¥ 1485 中国库存现货
50ug ¥ 3195 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
生物活性

重组人GPNMB (糖蛋白非转移性黑色素瘤 B) 蛋白由哺乳动物表达系统产生,编码 Ala22-Pro486 的靶基因在 C 末端用 6His 标签表达。骨激活素是一种细胞内糖蛋白,属于 NMB/pMEL-17 家族,与细胞内体/溶酶体区室相关。表达骨激活素的细胞包括成纤维细胞、成骨细胞、骨髓树突细胞、黑素细胞,以及胎儿软骨细胞和基底层角质形成细胞、巨噬细胞/角质形成细胞。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml
储存条件 Stored at ≤ -20°C, stable for one year after receipt
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] M Liguori, et al. Cell Mol Immunol. The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33

[2] Matthew L Neal, et al. J Neuroinflammation. The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

[3] Moses O Oyewumi, et al. Oncotarget. Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells

[4] Aifu Lin, et al. Nat Cell Biol. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

[5] Yu-Liang Wang, et al. Int J Clin Exp Pathol. Effects of GPNMB on proliferation and odontoblastic differentiation of human dental pulp cells

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