Recombinant Human GAS6 Protein (HEK293, C-6His) 别名：growth arrest-specific 6; 重组人GAS6 蛋白 (HEK293, C-6His)
GAS6 (Growth arrest-specific protein 6) also known as AXL receptor tyrosine kinase ligand, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest.
化学性质/溶解性/储存
| 性状 | Solution |
| 中文名称 | 重组人GAS6 蛋白 (HEK293, C-6His) |
| 储存条件 | Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
生物活性
GAS6 (Growth arrest-specific protein 6) also known as AXL receptor tyrosine kinase ligand, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer.
Recombinant Human GAS6 expressed the target gene encoding Ala31-Ala678 with a 6His tag at the C-terminus.
Immobilized Human AXL-His at 10μg/ml (100 μl/well) can bind Human GAS6, the tested ED50 of Recombinant Human GAS6 is 0.04466 ug/ml.
Accession: Q14393-2
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 80-90 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
The product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.
实验参考
建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。
请在下面的计算器中，输入您的动物实验相关数据并点击计算，即可得到该实验的总需药量和工作液终浓度。
例如您给药剂量是10 mg/kg，平均每只动物的体重为20 g，每只动物的给药体积是100 μL，动物数量为20只，则该动物实验的总需药量为4 mg，工作液终浓度为2 mg/mL。
1：鉴于实验过程的损耗，建议您至少多配1-2只动物的量；
2：为该产品最终给药时的浓度。
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