IL-2受体系统由三个非共价连接的亚基组成，分别是IL-2Rα、IL-2Rβ和IL-2Rγ。IL-2Rα是一种I型跨膜蛋白，由219个氨基酸组成的胞外结构域、19个跨膜结构域和13个胞内结构域，不参与IL-2信号转导。
别名：CD25 antigen; CD25; IDDM10
种属：Human
表达系统：HEK 293
纯度：SDS-PAGE分析，> 95%
内毒素：凝胶凝血法测定蛋白质< 0.2 EU/μg
表观分子量：65~ 75kda，还原条件下在SDS-PAGE上进行
存储及稳定性：在接收后，该产品在低于-70°C的环境下保持稳定长达6个月。重组后，产品应在4°C下稳定1周或在-20°C下稳定3个月。为了长期保存，建议添加载体蛋白(如0.1% BSA)。避免反复的冻融循环。
生物活性：5.0 μg/ml (100 μ l/孔)固定化的人IL-2可与CD25/IL-2Rα、hFc、人IL-2Rα结合。活化T细胞、调节性T细胞(Tregs)和NK细胞高水平表达CD25，高亲和力IL-2Rα的表达主要局限于这些细胞群。通过IL-2Rα信号通路介导各种细胞群的多种生物学过程，如B细胞和NK细胞的增殖和分化。可溶性形式的IL-2Rα (IL-2Rα)出现在血清中，伴随其在细胞上的表达增加。可溶性IL-2Rα的功能尚不清楚。据报道，生物体液中IL-2Rα水平的增加与T细胞和B细胞激活和免疫系统激活的增加相关。血清中IL-2Rα的浓度在多种炎症和某些白血病和淋巴瘤过程中均有升高。
| 溶解性（25°C） | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. |
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究