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Recombinant Human Cathepsin B (CHO,His) 重组人Cathepsin B蛋白(CHO,His)

目录号 M11252 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Cathepsin B是一种酶促蛋白,是肽酶(或蛋白酶)家族的成员。

Recombinant Human Cathepsin B (CHO,His)结构式

别名:Cathepsin B; APP secretase; APPS

规格 价格 库存状态
10ug ¥ 3015 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
生物活性

种属:Human

纯度:SDS-PAGE分析,> 95%

内毒素水平:凝胶凝血法测定蛋白质< 0.2 EU/μg

表观分子量:~43 kDa,还原条件下在SDS-PAGE上

存储及稳定性:在接收后,该产品在-20°C或以下可保持6个月的稳定,在4°C可保持1-2周。如需长期储存,应在-70°C或以下储存。避免反复的冻融循环


生物活性:组织蛋白酶B水平升高可发生在多种疾病中,引起多种病理变化,包括细胞死亡、炎症和有毒多肽的产生。例如,神经科学研究表明,组织蛋白酶B在诱导癫痫中发挥作用,导致大量细胞死亡。组织蛋白酶B抑制剂治疗的癫痫发作诱导大鼠表现出改善的神经评分和学习能力,神经元细胞死亡减少。

化学性质
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Annette V Jacobsen, et al. Cell Death Dis. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

[2] Joseph Carver, et al. PLoS One. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein

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