Recombinant Human 4-1BB Ligand Protein (HEK293) 重组人4-1BB Ligand蛋白 (HEK293)

目录号 M11391 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

Recombinant Human 4-1BB Ligand Protein (HEK293) 蛋白序列：DNA 序列编码人 4-1BB Ligand（NP_003802.1）表达带有 Fc 标签在 C 末端生物活性：固定人 4-1BB (His 标签)的浓度是 1ug/mL (100 μL/孔)能够结合 4-1BB 配体(Fc 标签)的线性范围是 1.25-20ug/mL

Recombinant Human 4-1BB Ligand Protein (HEK293)结构式

规格	价格	库存状态
50ug	¥ 5850	中国库存现货
100ug	¥ 9450	中国库存现货

其他规格数量报价？

质量标准及产品资料

纯度： ≥95% , Endotoxin ＜0.1EU/μg
COA
MSDS

产品信息

生物活性

表达宿主：人HEK293细胞

分子别名：4- 1BB Ligand、TNFSF9、CD137L

分子量：重组人 4-1BB Ligand 蛋白包含 467 个氨基酸，预测理论分子量为 51kd

纯度：≥95%采用SDS-PAGE凝胶和高效液相色谱分析

内毒素：＜0.1EU/μg

存储及稳定性：冻干制剂可在 4℃保存 24 个月，溶解后的液体可置于-20℃保存 6-12 个月，避免反复冻融

生物活性：肿瘤坏死因子配体超家族成员 9（4-1BBL）也被称为 4-1BB 配体 CD137L 或 TNFSF9，它是一种结合 TNFRSF9的细胞因子。4-1BBL 是 4-1BB 的高亲和力配体。4-1BBL 诱导活化的外周血 T 细胞增殖。此外，4-1BBL 可能在活化诱导的细胞死亡（AICD）中起作用。此外，4-1BBL 可能在T 细胞和 B 细胞/巨噬细胞之间的同源相互作用中发挥作用。至于疾病方面，4-1BBL 涉及癌症、传染病和自身免疫性疾病。

化学性质

储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

参考文献

[1] Shannon L McArdel, et al. Cancer Immunol Immunother. Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15

[2] Shannon K Oda, et al. J Exp Med. A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

[3] Angela C Boroughs, et al. Mol Ther. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

[4] Marta Trb, et al. J Immunother Cancer. Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

[5] Nathalie Bonnefoy, et al. Med Sci (Paris). [Next generation of anti-immune checkpoints antibodies]

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Recombinant Human 4-1BB Ligand Protein (HEK293) 重组人4-1BB Ligand蛋白 (HEK293)

目录号 M11391 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

质量标准及产品资料

生物活性

化学性质

参考文献

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