N-Lactoyl-Phenylalanine  别名：Lac-Phe

N-Lactoyl-Phenylalanine是一种可由运动诱导的血源性信号代谢物，能抑制进食和肥胖，可用于肥胖研究。

General animal information（仅供参考）

Animal experiments were performed according to procedure approved by the Stanford University Administrative Panel on Laboratory Animal Care (APLAC). Studies with ABCC5-KO mice were approved by the Institute Animal Care and use Committee of the Netherlands Cancer Institute. Mice were maintained in 12-hr light-dark cycles at 22 °C and ~50% relative humidity and fed a standard irradiated rodent chow diet. Where indicated, high-fat diet (Research Diets 60% kcal from fat) was used. Male C57BL/6J and male C57BL/6J DIO mice were purchased from Jackson Laboratory. Male C57BL/6NCrl mice were purchased from Charles River Laboratory. Whole body CNDP2-KO mice were obtained from the Mutant Mouse Regional Resource Center, a NCRR-NIH funded strain repository. ABCC5-KO mice were obtained from De Wolf et al.28 For in vivo injection of mice with compounds including Lac-Phe, lactate, and phenylalanine, compounds were dissolved in 18:1:1 (by volume) of saline/Kolliphor EL/DMSO. Compounds were administered to mice daily via intraperitoneal injections at 5 μl/g body weight at the indicated doses. For all injection experiments, mice were mock injected with the vehicle for 3–5 days until body weights have stabilized. For glucose tolerance tests, mice were fasted for 6 hours then injected with glucose at 10 μl/g body weight. A dose of 1 g/kg was used for the GTT of vehicle and Lac-Phe treated obese mice. Sample sizes were determined on the basis of previous experiments using similar methodologies. For metabolite administration experiments, mice were randomly assigned to treatment groups. Experimenters were not blinded to groups.