Brincidofovir  别名：CMX001; HDP-CDV; 布林西多福韦

Brincidofovir (CMX001)，是Cidofovir的脂质偶联前体化合物，具有长效抗病毒作用，Brincidofovir 对广泛的 DNA 病毒具有活性，包括巨细胞病毒 (CMV)、腺病毒 (ADV)、水痘带状疱疹病毒、单纯疱疹病毒、多瘤病毒、乳头瘤病毒、痘病毒和混合双链 DNA 病毒感染。

In vivo experiment: (for reference only)

Brincidofovir (CMX001) was suspended in 0.4% carboxymethylcellulose (CMC) for oral delivery to mice. Acyclovir (ACV) was weighed and suspended in sterile water for oral treatment of mice. Compounds were prepared in a 0.2 ml volume which was administered once daily (CMX001) or twice daily (ACV). Treatments for efficacy evaluations were administered to mice for 7 consecutive days beginning 24-72 h post viral inoculation by oral gavage using doses of 5, 2.5 and 1.25 mg/kg of CMX001 administered once daily or doses of 120, 60 or 30 mg/kg of ACV given twice daily at approximately 12 h intervals. For pathogenesis experiments, treatments began 24 h post viral inoculation and were administered for 7 consecutive days using 5 mg/kg of CMX001 or 100 mg/kg of ACV. These doses were selected based upon the results obtained in the mortality experiments.