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TLR Toll-like Receptor

抑制剂

目录号 产品名称 产品简介
M9904 ODN 1826 ODN 1826 is a class B CpG ODN specific for murine TLR9.
M9746 CU-CPT-8m CU-CPT-8m是一种特异性的TLR8(toll-like receptor 8)拮抗剂,其IC50值为67 nM,Kd值为220 nM。
M9742 CU-CPT-9a CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
M9741 CU-CPT9b CU-CPT9b is a potent and selective TLR8 inhibitor, with an IC50 of 0.7 nM.
M9692 IAXO-102 IAXO-102是一种TLR4的拮抗剂,抑制TLR4信号通路。
M9651 TLR4-IN-C34 C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
M9427 CU-CPT17e CU-CPT17e是一种有效的Toll样受体(TLR)激动剂,它可以激活TLR3,TLR8和TLR9。
M9289 E6446 dihydrochloride E6446 dihydrochloride是一种有效的,核酸感应TLR7和TLR9的合成拮抗剂。
M9204 Pam3CSK4 Pam3CSK4是一个Toll样受体1/2(TLR1/2)的激动剂。
M9063 TLR2-IN-C29 TLR2-IN-C29 是一种Toll-like receptor 2 (TLR2) 抑制剂。
M7189 Resiquimod Resiquimod is a toll-like receptor 7 (TLR7) agonist.
M5800 Motolimod (VTX-2337) Motolimod (VTX-2337)是一种选择性且有效的Toll-like receptor (TLR) 8激动剂,EC50为100 nM, 比作用于TLR7的选择性高50倍以上。Phase 2。
M5105 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively.
M4838 TAK-242 TAK-242 (Resatorvid)是TLR4信号通路抑制剂,能通过结合TLR4胞内区域抑制脂多糖诱导的炎症介质的产生。
M2728 GS-9620 GS-9620是一种口服有效的,选择性小分子Toll-like receptor 7激动剂。
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TAK-242

TAK-242 (Resatorvid)是TLR4信号通路抑制剂,能通过结合TLR4胞内区域抑制脂多糖诱导的炎症介质的产生。



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