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Recombinant Mouse HMGB1 Protein (HEK293, hFc Tag) 重组小鼠HMGB1蛋白 (HEK293, hFc Tag)

目录号 M22496 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组小鼠HMGB1蛋白 是二硫键连接的同型二聚体,包含 475 个氨基酸并且具有 53.3 kDa 的计算分子量。高迁移率族蛋白 1 (HMGB1),也称为 HMG-1,是 HMGB 家族的成员。HMGB1 是一种 DNA 结合核蛋白,在细胞因子刺激后主动释放,在细胞死亡期间被动释放。

Recombinant Mouse HMGB1 Protein (HEK293, hFc Tag)结构式

别名:High-mobility group box 1; HMG-1

规格 价格 库存状态
50ug ¥ 8145 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >85%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
生物活性

重组小鼠HMGB1蛋白 是二硫键连接的同型二聚体,包含 475 个氨基酸并且具有 53.3 kDa 的计算分子量。高迁移率族蛋白 1 (HMGB1),也称为 HMG-1,是 HMGB 家族的成员。

HMGB1 是一种 DNA 结合核蛋白,在细胞因子刺激后主动释放,在细胞死亡期间被动释放。HMGB1 促进蛋白水解酶的活性,破骨细胞需要 HMGB1 才能实现功能成熟。作为一种非组蛋白核蛋白,HMGB1具有双重功能。

在细胞内,HMGB1 结合 DNA,调节转录并决定染色体结构。在细胞外,HMGB1 可作为警报素激活先天系统并介导广泛的生理和病理反应。细胞外 HMGB1 也可作为一种有效的促炎细胞因子,促进多种炎症和感染性疾病的发病机制。

编码小鼠 HMGB1 (P63158) (Met 1-Glu 215) 的 DNA 序列在 N 末端与人 IgG1 的 Fc 区融合。

剂型描述:从无菌 PBS 中冻干,pH 7.4。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml
储存条件 Stable for up to twelve months from date of receipt at -20℃ to -80℃
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] YaQing Zhan, et al. J Immunol. HMGB1-Mediated Neutrophil Extracellular Trap Formation Exacerbates Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury

[2] Min Zhao, et al. J Exp Clin Cancer Res. YAP promotes autophagy and progression of gliomas via upregulating HMGB1

[3] Zhen Wang, et al. Autophagy. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

[4] Ben Lu, et al. Nature. Novel role of PKR in inflammasome activation and HMGB1 release

[5] A Tesniere, et al. Oncogene. Immunogenic death of colon cancer cells treated with oxaliplatin

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