重组小鼠HMGB1蛋白 是二硫键连接的同型二聚体,包含 475 个氨基酸并且具有 53.3 kDa 的计算分子量。高迁移率族蛋白 1 (HMGB1),也称为 HMG-1,是 HMGB 家族的成员。HMGB1 是一种 DNA 结合核蛋白,在细胞因子刺激后主动释放,在细胞死亡期间被动释放。
别名:High-mobility group box 1; HMG-1
重组小鼠HMGB1蛋白 是二硫键连接的同型二聚体,包含 475 个氨基酸并且具有 53.3 kDa 的计算分子量。高迁移率族蛋白 1 (HMGB1),也称为 HMG-1,是 HMGB 家族的成员。
HMGB1 是一种 DNA 结合核蛋白,在细胞因子刺激后主动释放,在细胞死亡期间被动释放。HMGB1 促进蛋白水解酶的活性,破骨细胞需要 HMGB1 才能实现功能成熟。作为一种非组蛋白核蛋白,HMGB1具有双重功能。
在细胞内,HMGB1 结合 DNA,调节转录并决定染色体结构。在细胞外,HMGB1 可作为警报素激活先天系统并介导广泛的生理和病理反应。细胞外 HMGB1 也可作为一种有效的促炎细胞因子,促进多种炎症和感染性疾病的发病机制。
编码小鼠 HMGB1 (P63158) (Met 1-Glu 215) 的 DNA 序列在 N 末端与人 IgG1 的 Fc 区融合。
剂型描述:从无菌 PBS 中冻干,pH 7.4。
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml |
储存条件 | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
[4] Ben Lu, et al. Nature. Novel role of PKR in inflammasome activation and HMGB1 release
[5] A Tesniere, et al. Oncogene. Immunogenic death of colon cancer cells treated with oxaliplatin
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