蛋白构建：将编码人CCL5 (Ser24-Ser91)的DNA序列与GST标记融合 生物活性：对血液单核细胞，记忆t辅助细胞和嗜酸性粒细胞的趋化剂。引起嗜碱性粒细胞释放组胺并激活嗜酸性粒细胞。
种属：Homo sapiens (Human)
预测分子量：33.46 kDa
纯度:SDS-PAGE测定为>90%
稳定性及存储：使用手动融霜冰箱，避免重复冻融循环。 在2 - 8°C保存一周。 自收到之日起，在-20至-80°C保存12个月。
生物活性：可激活多种趋化因子受体，包括CCR1、CCR3、CCR4和CCR5。一种主要的hiv抑制因子由CD8+ t细胞产生。重组RANTES蛋白诱导了对HIV-1、HIV-2和猿类免疫缺陷病毒(SIV)不同毒株的剂量依赖性抑制。加工过的RANTES(3-68)作为一种天然趋化抑制剂，是一种更有效的hiv -1感染抑制剂。与RANTES(1-68)和RANTES(3-68)相比，第二种经过处理的RANTES(4-68)表现出较低的趋化性和抑制hiv的活性，它是由一种与单核细胞和中性粒细胞相关的未知酶产生的。也可能是G蛋白偶联受体GPR75的激动剂，通过其激活刺激肌醇三磷酸的产生和钙的动员。与GPR75一起，可能通过激活涉及PI3、Akt和MAP激酶的下游信号通路，在神经元存活中发挥作用。通过激活GPR75也可能对胰岛细胞分泌胰岛素起作用。
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究