HWY336 is a selective, non-ATP competitive dual MKK4 and MKK7 inhibitor with IC50 values of 6 µM on MKK4 and 10 µM on MKK7 in vitro. HWY336 inhibits the phosphorylation of MKK4/MKK7 inside the activation loop or hinders the substrate to access the kinase.
别名：HWY-336
HWY336 is a selective, non-ATP competitive dual MKK4 and MKK7 inhibitor with IC50 values of 6 µM on MKK4 and 10 µM on MKK7 in vitro. HWY336 inhibits the phosphorylation of MKK4/MKK7 inside the activation loop or hinders the substrate to access the kinase. HEK293T cells that were treated with D-sorbitol, to activate JNK, were incubated with HWY336 in increasing concentrations. The phosphorylation of JNKs was reduced after 3 h of incubation with 9 µM HWY336 and disappeared after 4 h of treatment with 12 µM HWY336. These experiments and the performed wash experiments indicate that the inhibition is directed to MKK4, is reversible and is non-covalent.
| 储存条件 |
粉末型式 -20°C 3年；4°C 2年 溶于溶剂 -80°C 6个月；-20°C 1个月 |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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